Search Results

Overview

Uniprot IDO60271
Protein NameC-Jun-amino-terminal kinase-interacting protein 4
Gene NameSPAG9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1140 SKMLGTGKLGFSFVR
178 MEHLERTKLHQLSGS
373 PTKGIENKAFDRNTE
577 PEPPVNLKYNAPTSH
591 HVTPSVKKRSSTLSQ
603 LSQLPGDKSKAFDFL
605 QLPGDKSKAFDFLSE

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity)

Protein Sequence

10 MELEDGVVYQ 20 EEPGGSGAVM 30 SERVSGLAGS 40 IYREFERLIG 50 RYDEEVVKEL 60 MPLVVAVLEN 70 LDSVFAQDQE 80 HQVELELLRD 90 DNEQLITQYE 100 REKALRKHAE 110 EKFIEFEDSQ 120 EQEKKDLQTR 130 VESLESQTRQ 140 LELKAKNYAD 150 QISRLEEREA 160 ELKKEYNALH 170 QRHTEMIHNY 180 MEHLERTKLH 190 QLSGSDQLES 200 TAHSRIRKER 210 PISLGIFPLP 220 AGDGLLTPDA 230 QKGGETPGSE 240 QWKFQELSQP 250 RSHTSLKVSN 260 SPEPQKAVEQ 270 EDELSDVSQG 280 GSKATTPAST 290 ANSDVATIPT 300 DTPLKEENEG 310 FVKVTDAPNK 320 SEISKHIEVQ 330 VAQETRNVST 340 GSAENEEKSE 350 VQAIIESTPE 360 LDMDKDLSGY 370 KGSSTPTKGI 380 ENKAFDRNTE 390 SLFEELSSAG 400 SGLIGDVDEG 410 ADLLGMGREV 420 ENLILENTQL 430 LETKNALNIV 440 KNDLIAKVDE 450 LTCEKDVLQG 460 ELEAVKQAKL 470 KLEEKNRELE 480 EELRKARAEA 490 EDARQKAKDD 500 DDSDIPTAQR 510 KRFTRVEMAR 520 VLMERNQYKE 530 RLMELQEAVR 540 WTEMIRASRE 550 NPAMQEKKRS 560 SIWQFFSRLF 570 SSSSNTTKKP 580 EPPVNLKYNA 590 PTSHVTPSVK 600 KRSSTLSQLP 610 GDKSKAFDFL 620 SEETEASLAS 630 RREQKREQYR 640 QVKAHVQKED 650 GRVQAFGWSL 660 PQKYKQVTNG 670 QGENKMKNLP 680 VPVYLRPLDE 690 KDTSMKLWCA 700 VGVNLSGGKT 710 RDGGSVVGAS 720 VFYKDVAGLD 730 TEGSKQRSAS 740 QSSLDKLDQE 750 LKEQQKELKN 760 QEELSSLVWI 770 CTSTHSATKV 780 LIIDAVQPGN 790 ILDSFTVCNS 800 HVLCIASVPG 810 ARETDYPAGE 820 DLSESGQVDK 830 ASLCGSMTSN 840 SSAETDSLLG 850 GITVVGCSAE 860 GVTGAATSPS 870 TNGASPVMDK 880 PPEMEAENSE 890 VDENVPTAEE 900 ATEATEGNAG 910 SAEDTVDISQ 920 TGVYTEHVFT 930 DPLGVQIPED 940 LSPVYQSSND 950 SDAYKDQISV 960 LPNEQDLVRE 970 EAQKMSSLLP 980 TMWLGAQNGC 990 LYVHSSVAQW 1000 RKCLHSIKLK 1010 DSILSIVHVK 1020 GIVLVALADG 1030 TLAIFHRGVD 1040 GQWDLSNYHL 1050 LDLGRPHHSI 1060 RCMTVVHDKV 1070 WCGYRNKIYV 1080 VQPKAMKIEK 1090 SFDAHPRKES 1100 QVRQLAWVGD 1110 GVWVSIRLDS 1120 TLRLYHAHTY 1130 QHLQDVDIEP 1140 YVSKMLGTGK 1150 LGFSFVRITA 1160 LMVSCNRLWV 1170 GTGNGVIISI 1180 PLTETNKTSG 1190 VPGNRPGSVI 1200 RVYGDENSDK 1210 VTPGTFIPYC 1220 SMAHAQLCFH 1230 GHRDAVKFFV 1240 AVPGQVISPQ 1250 SSSSGTDLTG 1260 DKAGPSAQEP 1270 GSQTPLKSML 1280 VISGGEGYID 1290 FRMGDEGGES 1300 ELLGEDLPLE 1310 PSVTKAERSH 1320 LIVWQVMYGN E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008432 JUN kinase binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0005078 MAP-kinase scaffold activity
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0032418 lysosome localization
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.