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Overview

Uniprot IDO60282
Protein NameKinesin heavy chain isoform 5C
Gene NameKIF5C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
241 AGSEKVSKTGAEGAV
776 KLLLLNDKREQARED

Function

Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity)

Protein Sequence

10 MADPAECSIK 20 VMCRFRPLNE 30 AEILRGDKFI 40 PKFKGDETVV 50 IGQGKPYVFD 60 RVLPPNTTQE 70 QVYNACAKQI 80 VKDVLEGYNG 90 TIFAYGQTSS 100 GKTHTMEGKL 110 HDPQLMGIIP 120 RIAHDIFDHI 130 YSMDENLEFH 140 IKVSYFEIYL 150 DKIRDLLDVS 160 KTNLAVHEDK 170 NRVPYVKGCT 180 ERFVSSPEEV 190 MDVIDEGKAN 200 RHVAVTNMNE 210 HSSRSHSIFL 220 INIKQENVET 230 EKKLSGKLYL 240 VDLAGSEKVS 250 KTGAEGAVLD 260 EAKNINKSLS 270 ALGNVISALA 280 EGTKTHVPYR 290 DSKMTRILQD 300 SLGGNCRTTI 310 VICCSPSVFN 320 EAETKSTLMF 330 GQRAKTIKNT 340 VSVNLELTAE 350 EWKKKYEKEK 360 EKNKTLKNVI 370 QHLEMELNRW 380 RNGEAVPEDE 390 QISAKDQKNL 400 EPCDNTPIID 410 NIAPVVAGIS 420 TEEKEKYDEE 430 ISSLYRQLDD 440 KDDEINQQSQ 450 LAEKLKQQML 460 DQDELLASTR 470 RDYEKIQEEL 480 TRLQIENEAA 490 KDEVKEVLQA 500 LEELAVNYDQ 510 KSQEVEDKTR 520 ANEQLTDELA 530 QKTTTLTTTQ 540 RELSQLQELS 550 NHQKKRATEI 560 LNLLLKDLGE 570 IGGIIGTNDV 580 KTLADVNGVI 590 EEEFTMARLY 600 ISKMKSEVKS 610 LVNRSKQLES 620 AQMDSNRKMN 630 ASERELAACQ 640 LLISQHEAKI 650 KSLTDYMQNM 660 EQKRRQLEES 670 QDSLSEELAK 680 LRAQEKMHEV 690 SFQDKEKEHL 700 TRLQDAEEMK 710 KALEQQMESH 720 REAHQKQLSR 730 LRDEIEEKQK 740 IIDEIRDLNQ 750 KLQLEQEKLS 760 SDYNKLKIED 770 QEREMKLEKL 780 LLLNDKREQA 790 REDLKGLEET 800 VSRELQTLHN 810 LRKLFVQDLT 820 TRVKKSVELD 830 NDDGGGSAAQ 840 KQKISFLENN 850 LEQLTKVHKQ 860 LVRDNADLRC 870 ELPKLEKRLR 880 ATAERVKALE 890 SALKEAKENA 900 MRDRKRYQQE 910 VDRIKEAVRA 920 KNMARRAHSA 930 QIAKPIRPGH 940 YPASSPTAVH 950 AIRGGGGSSS NSTHYQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0044295 axonal growth cone
Cellular Component GO:0035253 ciliary rootlet
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0032839 dendrite cytoplasm
Cellular Component GO:0150034 distal axon
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0099524 postsynaptic cytosol
Molecular Function GO:0034190 apolipoprotein receptor binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0008574 plus-end-directed microtubule motor activity
Biological Process GO:0099641 anterograde axonal protein transport
Biological Process GO:0098964 anterograde dendritic transport of messenger ribonucleoprotein complex
Biological Process GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex
Biological Process GO:0007411 axon guidance
Biological Process GO:0008298 intracellular mRNA localization
Biological Process GO:0051028 mRNA transport
Biological Process GO:0006996 organelle organization
Biological Process GO:0048489 synaptic vesicle transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.