Search Results

Overview

Uniprot IDO60284
Protein NameSuppression of tumorigenicity 18 protein
Gene NameST18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
227 KYVLTDHKKDLLEVP

Function

Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells

Protein Sequence

10 MDAEAEDKTL 20 RTRSKGTEVP 30 MDSLIQELSV 40 AYDCSMAKKR 50 TAEDQALGVP 60 VNKRKSLLMK 70 PRHYSPKADC 80 QEDRSDRTED 90 DGPLETHGHS 100 TAEEIMIKPM 110 DESLLSTAQE 120 NSSRKEDRYS 130 CYQELMVKSL 140 MHLGKFEKNV 150 SVQTVSENLN 160 DSGIQSLKAE 170 SDEADECFLI 180 HSDDGRDKID 190 DSQPPFCSSD 200 DNESNSESAE 210 NGWDSGSNFS 220 EETKPPRVPK 230 YVLTDHKKDL 240 LEVPEIKTEG 250 DKFIPCENRC 260 DSETERKDPQ 270 NALAEPLDGN 280 AQPSFPDVEE 290 EDSESLAVMT 300 EEGSDLEKAK 310 GNLSLLEQAI 320 ALQAERGCVF 330 HNTYKELDRF 340 LLEHLAGERR 350 QTKVIDMGGR 360 QIFNNKHSPR 370 PEKRETKCPI 380 PGCDGTGHVT 390 GLYPHHRSLS 400 GCPHKVRVPL 410 EILAMHENVL 420 KCPTPGCTGR 430 GHVNSNRNTH 440 RSLSGCPIAA 450 AEKLAMSQDK 460 NQLDSPQTGQ 470 CPDQAHRTSL 480 VKQIEFNFPS 490 QAITSPRATV 500 SKEQEKFGKV 510 PFDYASFDAQ 520 VFGKRPLIQT 530 VQGRKTPPFP 540 ESKHFPNPVK 550 FPNRLPSAGA 560 HTQSPGRASS 570 YSYGQCSEDT 580 HIAAAAAILN 590 LSTRCREATD 600 ILSNKPQSLH 610 AKGAEIEVDE 620 NGTLDLSMKK 630 NRILDKSAPL 640 TSSNTSIPTP 650 SSSPFKTSSI 660 LVNAAFYQAL 670 CDQEGWDTPI 680 NYSKTHGKTE 690 EEKEKDPVSS 700 LENLEEKKFP 710 GEASIPSPKP 720 KLHARDLKKE 730 LITCPTPGCD 740 GSGHVTGNYA 750 SHRSVSGCPL 760 ADKTLKSLMA 770 ANSQELKCPT 780 PGCDGSGHVT 790 GNYASHRSLS 800 GCPRARKGGV 810 KMTPTKEEKE 820 DPELKCPVIG 830 CDGQGHISGK 840 YTSHRTASGC 850 PLAAKRQKEN 860 PLNGASLSWK 870 LNKQELPHCP 880 LPGCNGLGHV 890 NNVFVTHRSL 900 SGCPLNAQVI 910 KKGKVSEELM 920 TIKLKATGGI 930 ESDEEIRHLD 940 EEIKELNESN 950 LKIEADMMKL 960 QTQITSMESN 970 LKTIEEENKL 980 IEQNNESLLK 990 ELAGLSQALI 1000 SSLADIQLPQ 1010 MGPISEQNFE 1020 AYVNTLTDMY 1030 SNLERDYSPE 1040 CKALLESIKQ AVKGIHV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032993 protein-DNA complex
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.