Search Results

Overview

Uniprot IDO60292
Protein NameSignal-induced proliferation-associated 1-like protein 3
Gene NameSIPA1L3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1115 QSLSRPLKQTPIVPF

Function

Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217)

Protein Sequence

10 MTTYRAIPSD 20 GVDLAASCGA 30 RVGDVLPGPH 40 TGDYAPLGFW 50 AQNGSMSQPL 60 GESPATATAT 70 ATATTRPSPT 80 TPAMPKMGVR 90 ARVADWPPKR 100 EALREHSNPS 110 PSQDTDGTKA 120 TKMAHSMRSI 130 QNGQPPTSTP 140 ASSGSKAFHR 150 LSRRRSKDVE 160 FQDGWPRSPG 170 RAFLPLRHRS 180 SSEITLSECD 190 AEDAGEPRGA 200 RHTGALPLFR 210 EYGSTSSIDV 220 QGMPEQSFFD 230 ILNEFRSEQP 240 DARGCQALTE 250 LLRADPGPHL 260 MGGGGGAKGD 270 SHNGQPAKDS 280 LLPLQPTKEK 290 EKARKKPARG 300 LGGGDTVDSS 310 IFRKLRSSKP 320 EGEAGRSPGE 330 ADEGRSPPEA 340 SRPWVCQKSF 350 AHFDVQSMLF 360 DLNEAAANRV 370 SVSQRRNTTT 380 GASAASAASA 390 MASLTASRAH 400 SLGGLDPAFT 410 STEDLNCKEN 420 LEQDLGDDNS 430 NDLLLSCPHF 440 RNEIGGECER 450 NVSFSRASVG 460 SPSSGEGHLA 470 EPALSAYRTN 480 ASISVLEVPK 490 EQQRTQSRPR 500 QYSIEHVDLG 510 ARYYQDYFVG 520 KEHANYFGVD 530 EKLGPVAVSI 540 KREKLEDHKE 550 HGPQYQYRII 560 FRTRELITLR 570 GSILEDATPT 580 ATKHGTGRGL 590 PLKDALEYVI 600 PELNIHCLRL 610 ALNTPKVTEQ 620 LLKLDEQGLC 630 RKHKVGILYC 640 KAGQSSEEEM 650 YNNEEAGPAF 660 EEFLSLIGEK 670 VCLKGFTKYA 680 AQLDVKTDST 690 GTHSLYTMYQ 700 DYEIMFHVST 710 LLPYTPNNRQ 720 QLLRKRHIGN 730 DIVTIIFQEP 740 GALPFTPKNI 750 RSHFQHVFII 760 VRVHNPCTDN 770 VCYSMAVTRS 780 KDAPPFGPPI 790 PSGTTFRKSD 800 VFRDFLLAKV 810 INAENAAHKS 820 DKFHTMATRT 830 RQEYLKDLAE 840 NCVSNTPIDS 850 TGKFNLISLT 860 SKKKEKTKAR 870 AGAEQHSAGA 880 IAWRVVAQDY 890 AQGVEIDCIL 900 GISNEFVVLL 910 DLRTKEVVFN 920 CYCGDVIGWT 930 PDSSTLKIFY 940 GRGDHIFLQA 950 TEGSVEDIRE 960 IVQRLKVMTS 970 GWETVDMTLR 980 RNGLGQLGFH 990 VKYDGTVAEV 1000 EDYGFAWQAG 1010 LRQGSRLVEI 1020 CKVAVVTLTH 1030 DQMIDLLRTS 1040 VTVKVVIIPP 1050 FEDGTPRRGW 1060 PETYDMNTSE 1070 PKTEQESITP 1080 GGRPPYRSNA 1090 PWQWSGPASH 1100 NSLPASKWAT 1110 PTTPGHAQSL 1120 SRPLKQTPIV 1130 PFRESQPLHS 1140 KRPVSFPETP 1150 YTVSPAGADR 1160 VPPYRQPSGS 1170 FSTPGSATYV 1180 RYKPSPERYT 1190 AAPHPLLSLD 1200 PHFSHDGTSS 1210 GDSSSGGLTS 1220 QESTMERQKP 1230 EPLWHVPAQA 1240 RLSAIAGSSG 1250 NKHPSRQDAA 1260 GKDSPNRHSK 1270 GEPQYSSHSS 1280 SNTLSSNASS 1290 SHSDDRWFDP 1300 LDPLEPEQDP 1310 LSKGGSSDSG 1320 IDTTLYTSSP 1330 SCMSLAKAPR 1340 PAKPHKPPGS 1350 MGLCGGGREA 1360 AGRSHHADRR 1370 REVSPAPAVA 1380 GQSKGYRPKL 1390 YSSGSSTPTG 1400 LAGGSRDPPR 1410 QPSDMGSRVG 1420 YPAQVYKTAS 1430 AETPRPSQLA 1440 QPSPFQLSAS 1450 VPKSFFSKQP 1460 VRNKHPTGWK 1470 RTEEPPPRPL 1480 PFSDPKKQVD 1490 TNTKNVFGQP 1500 RLRASLRDLR 1510 SPRKNYKSTI 1520 EDDLKKLIIM 1530 DNLGPEQERD 1540 TGQSPQKGLQ 1550 RTLSDESLCS 1560 GRREPSFASP 1570 AGLEPGLPSD 1580 VLFTSTCAFP 1590 SSTLPARRQH 1600 QHPHPPVGPG 1610 ATPAAGSGFP 1620 EKKSTISASE 1630 LSLADGRDRP 1640 LRRLDPGLMP 1650 LPDTAAGLEW 1660 SSLVNAAKAY 1670 EVQRAVSLFS 1680 LNDPALSPDI 1690 PPAHSPVHSH 1700 LSLERGPPTP 1710 RTTPTMSEEP 1720 PLDLTGKVYQ 1730 LEVMLKQLHT 1740 DLQKEKQDKV 1750 VLQSEVASLR 1760 QNNQRLQEES 1770 QAASEQLRKF 1780 AEIFCREKKE L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0099091 postsynaptic specialization, intracellular component
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0061689 tricellular tight junction
Molecular Function GO:0005096 GTPase activator activity
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0003382 epithelial cell morphogenesis
Biological Process GO:0090162 establishment of epithelial cell polarity
Biological Process GO:0001654 eye development
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.