Search Results

Overview

Uniprot ID	O60293
Protein Name	Zinc finger C3H1 domain-containing protein
Gene Name	ZFC3H1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
428	KKVSTTAKQALRKQQ
490	EQYNRFMKLVGGKRR
687	QPRIQNPKFHRGPRL
703	RTVISLPKHKSVVVT

Function

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters

Protein Sequence

10 MATADTPAPA 20 SSGLSPKEEG 30 ELEDGEISDD 40 DNNSQIRSRS 50 SSSSSGGGLL 60 PYPRRRPPHS 70 ARGGGSGGGG 80 GSSSSSSSSQ 90 QQLRNFSRSR 100 HASERGHLRG 110 PSSYRPKEPF 120 RSHPPSVRMP 130 SSSLSESSPR 140 PSFWERSHLA 150 LDRFRFRGRP 160 YRGGSRWSRG 170 RGVGERGGKP 180 GCRPPLGGGA 190 GSGFSSSQSW 200 REPSPPRKSS 210 KSFGRSPSRK 220 QNYSSKNENC 230 VEETFEDLLL 240 KYKQIQLELE 250 CINKDEKLAL 260 SSKEENVQED 270 PKTLNFEDQT 280 STDNVSITKD 290 SSKEVAPEEK 300 TQVKTFQAFE 310 LKPLRQKLTL 320 PGDKNRLKKV 330 KDGAKPLSLK 340 SDTTDSSQGL 350 QDKEQNLTRR 360 ISTSDILSEK 370 KLGEDEEELS 380 ELQLRLLALQ 390 SASKKWQQKE 400 QQVMKESKEK 410 LTKTKTVQQK 420 VKTSTKTHSA 430 KKVSTTAKQA 440 LRKQQTKAWK 450 KLQQQKEQER 460 QKEEDQRKQA 470 EEEERRKREE 480 EIRKIRDLSN 490 QEEQYNRFMK 500 LVGGKRRSRS 510 KSSDPDLRRS 520 LDKQPTDSGG 530 GIYQYDNYEE 540 VAMDTDSETS 550 SPAPSPVQPP 560 FFSECSLGYF 570 SPAPSLSLPP 580 PPQVSSLPPL 590 SQPYVEGLCV 600 SLEPLPPLPP 610 LPPLPPEDPE 620 QPPKPPFADE 630 EEEEEMLLRE 640 ELLKSLANKR 650 AFKPEETSSN 660 SDPPSPPVLN 670 NSHPVPRSNL 680 SIVSINTVSQ 690 PRIQNPKFHR 700 GPRLPRTVIS 710 LPKHKSVVVT 720 LNDSDDSESD 730 GEASKSTNSV 740 FGGLESMIKE 750 ARRTAEQASK 760 PKVPPKSEKE 770 NDPLRTPEAL 780 PEEKKIEYRL 790 LKEEIANREK 800 QRLIKSDQLK 810 TSSSSPANSD 820 VEIDGIGRIA 830 MVTKQVTDAE 840 SKLKKHRILL 850 MKDESVLKNL 860 VQQEAKKKES 870 VRNAEAKITK 880 LTEQLQATEK 890 ILNVNRMFLK 900 KLQEQIHRVQ 910 QRVTIKKALT 920 LKYGEELARA 930 KAVASKEIGK 940 RKLEQDRFGP 950 NKMMRLDSSP 960 VSSPRKHSAE 970 LIAMEKRRLQ 980 KLEYEYALKI 990 QKLKEARALK 1000 AKEQQNISPV 1010 VEEEPEFSLP 1020 QPSLHDLTQD 1030 KLTLDTEEND 1040 VDDEILSGSS 1050 RERRRSFLES 1060 NYFTKPNLKH 1070 TDTANKECIN 1080 KLNKNTVEKP 1090 ELFLGLKIGE 1100 LQKLYSKADS 1110 LKQLILKTTT 1120 GITEKVLHGQ 1130 EISVDVDFVT 1140 AQSKTMEVKP 1150 CPFRPYHSPL 1160 LVFKSYRFSP 1170 YYRTKEKLPL 1180 SSVSYSNMIE 1190 PDQCFCRFDL 1200 TGTCNDDDCQ 1210 WQHIQDYTLS 1220 RKQLFQDILS 1230 YNLSLIGCAE 1240 TSTNEEITAS 1250 AEKYVEKLFG 1260 VNKDRMSMDQ 1270 MAVLLVSNIN 1280 ESKGHTPPFT 1290 TYKDKRKWKP 1300 KFWRKPISDN 1310 SFSSDEEQST 1320 GPIKYAFQPE 1330 NQINVPALDT 1340 VVTPDDVRYF 1350 TNETDDIANL 1360 EASVLENPSH 1370 VQLWLKLAYK 1380 YLNQNEGECS 1390 ESLDSALNVL 1400 ARALENNKDN 1410 PEIWCHYLRL 1420 FSKRGTKDEV 1430 QEMCETAVEY 1440 APDYQSFWTF 1450 LHLESTFEEK 1460 DYVCERMLEF 1470 LMGAAKQETS 1480 NILSFQLLEA 1490 LLFRVQLHIF 1500 TGRCQSALAI 1510 LQNALKSAND 1520 GIVAEYLKTS 1530 DRCLAWLAYI 1540 HLIEFNILPS 1550 KFYDPSNDNP 1560 SRIVNTESFV 1570 MPWQAVQDVK 1580 TNPDMLLAVF 1590 EDAVKACTDE 1600 SLAVEERIEA 1610 CLPLYTNMIA 1620 LHQLLERYEA 1630 AMELCKSLLE 1640 SCPINCQLLE 1650 ALVALYLQTN 1660 QHDKARAVWL 1670 TAFEKNPQNA 1680 EVFYHMCKFF 1690 ILQNRGDNLL 1700 PFLRKFIASF 1710 FKPGFEKYNN 1720 LDLFRYLLNI 1730 PGPIDIPSRL 1740 CKGNFDDDMF 1750 NHQVPYLWLI 1760 YCLCHPLQSS 1770 IKETVEAYEA 1780 ALGVAMRCDI 1790 VQKIWMDYLV 1800 FANNRAAGSR 1810 NKVQEFKFFT 1820 DLVNRCLVTV 1830 PARYPIPFSS 1840 ADYWSNYEFH 1850 NRVIFFYLSC 1860 VPKTQHSKTL 1870 ERFCSVMPAN 1880 SGLALRLLQH 1890 EWEESNVQIL 1900 KLQAKMFTYN 1910 IPTCLATWKI 1920 AIAAEIVLKG 1930 QREVHRLYQR 1940 ALQKLPLCAS 1950 LWKDQLLFEA 1960 SEGGKTDNLR 1970 KLVSKCQEIG 1980 VSLNELLNLN SNKTESKNH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:1990477	MTREC complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006401	RNA catabolic process
Biological Process	GO:0006396	RNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.