Search Results
Overview
| Uniprot ID | O60315 |
|---|---|
| Protein Name | Zinc finger E-box-binding homeobox 2 |
| Gene Name | ZEB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 332 | YSSHISSKKCIGLIS |
| 333 | SSHISSKKCIGLISV |
| 624 | HENIVPNKAGVFVDN |
Function
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212)
Protein Sequence
10
MKQPIMADGP
20
RCKRRKQANP
30
RRKNVVNYDN
40
VVDTGSETDE
50
EDKLHIAEDD
60
GIANPLDQET
70
SPASVPNHES
80
SPHVSQALLP
90
REEEEDEIRE
100
GGVEHPWHNN
110
EILQASVDGP
120
EEMKEDYDTM
130
GPEATIQTAI
140
NNGTVKNANC
150
TSDFEEYFAK
160
RKLEERDGHA
170
VSIEEYLQRS
180
DTAIIYPEAP
190
EELSRLGTPE
200
ANGQEENDLP
210
PGTPDAFAQL
220
LTCPYCDRGY
230
KRLTSLKEHI
240
KYRHEKNEEN
250
FSCPLCSYTF
260
AYRTQLERHM
270
VTHKPGTDQH
280
QMLTQGAGNR
290
KFKCTECGKA
300
FKYKHHLKEH
310
LRIHSGEKPY
320
ECPNCKKRFS
330
HSGSYSSHIS
340
SKKCIGLISV
350
NGRMRNNIKT
360
GSSPNSVSSS
370
PTNSAITQLR
380
NKLENGKPLS
390
MSEQTGLLKI
400
KTEPLDFNDY
410
KVLMATHGFS
420
GTSPFMNGGL
430
GATSPLGVHP
440
SAQSPMQHLG
450
VGMEAPLLGF
460
PTMNSNLSEV
470
QKVLQIVDNT
480
VSRQKMDCKA
490
EEISKLKGYH
500
MKDPCSQPEE
510
QGVTSPNIPP
520
VGLPVVSHNG
530
ATKSIIDYTL
540
EKVNEAKACL
550
QSLTTDSRRQ
560
ISNIKKEKLR
570
TLIDLVTDDK
580
MIENHNISTP
590
FSCQFCKESF
600
PGPIPLHQHE
610
RYLCKMNEEI
620
KAVLQPHENI
630
VPNKAGVFVD
640
NKALLLSSVL
650
SEKGMTSPIN
660
PYKDHMSVLK
670
AYYAMNMEPN
680
SDELLKISIA
690
VGLPQEFVKE
700
WFEQRKVYQY
710
SNSRSPSLER
720
SSKPLAPNSN
730
PPTKDSLLPR
740
SPVKPMDSIT
750
SPSIAELHNS
760
VTNCDPPLRL
770
TKPSHFTNIK
780
PVEKLDHSRS
790
NTPSPLNLSS
800
TSSKNSHSSS
810
YTPNSFSSEE
820
LQAEPLDLSL
830
PKQMKEPKSI
840
IATKNKTKAS
850
SISLDHNSVS
860
SSSENSDEPL
870
NLTFIKKEFS
880
NSNNLDNKST
890
NPVFSMNPFS
900
AKPLYTALPP
910
QSAFPPATFM
920
PPVQTSIPGL
930
RPYPGLDQMS
940
FLPHMAYTYP
950
TGAATFADMQ
960
QRRKYQRKQG
970
FQGELLDGAQ
980
DYMSGLDDMT
990
DSDSCLSRKK
1000
IKKTESGMYA
1010
CDLCDKTFQK
1020
SSSLLRHKYE
1030
HTGKRPHQCQ
1040
ICKKAFKHKH
1050
HLIEHSRLHS
1060
GEKPYQCDKC
1070
GKRFSHSGSY
1080
SQHMNHRYSY
1090
CKREAEEREA
1100
AEREAREKGH
1110
LEPTELLMNR
1120
AYLQSITPQG
1130
YSDSEERESM
1140
PRDGESEKEH
1150
EKEGEDGYGK
1160
LGRQDGDEEF
1170
EEEEEESENK
1180
SMDTDPETIR
1190
DEEETGDHSM
1200
DDSSEDGKME
1210
TKSDHEEDNM
EDGM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0019208 | phosphatase regulator activity |
| Molecular Function | GO:0070412 | R-SMAD binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0048143 | astrocyte activation |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0048066 | developmental pigmentation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0001935 | endothelial cell proliferation |
| Biological Process | GO:0072537 | fibroblast activation |
| Biological Process | GO:0097324 | melanocyte migration |
| Biological Process | GO:0036446 | myofibroblast differentiation |
| Biological Process | GO:0010764 | negative regulation of fibroblast migration |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:1902748 | positive regulation of lens fiber cell differentiation |
| Biological Process | GO:0048023 | positive regulation of melanin biosynthetic process |
| Biological Process | GO:0045636 | positive regulation of melanocyte differentiation |
| Biological Process | GO:1904330 | positive regulation of myofibroblast contraction |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0070269 | pyroptotic inflammatory response |
| Biological Process | GO:1905603 | regulation of blood-brain barrier permeability |
| Biological Process | GO:1903056 | regulation of melanosome organization |
| Biological Process | GO:1904520 | regulation of myofibroblast cell apoptotic process |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090649 | response to oxygen-glucose deprivation |
| Biological Process | GO:0043149 | stress fiber assembly |
Reference
PMID: N/A