Search Results

Overview

Uniprot IDO60343
Protein NameTBC1 domain family member 4
Gene NameTBC1D4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1291 LNCNPNNKAKIGNKP
555 ATSSGRFKLDILKNK

Function

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake

Protein Sequence

10 MEPPSCIQDE 20 PFPHPLEPEP 30 GVSAQPGPGK 40 PSDKRFRLWY 50 VGGSCLDHRT 60 TLPMLPWLMA 70 EIRRRSQKPE 80 AGGCGAPAAR 90 EVILVLSAPF 100 LRCVPAPGAG 110 ASGGTSPSAT 120 QPNPAVFIFE 130 HKAQHISRFI 140 HNSHDLTYFA 150 YLIKAQPDDP 160 ESQMACHVFR 170 ATDPSQVPDV 180 ISSIRQLSKA 190 AMKEDAKPSK 200 DNEDAFYNSQ 210 KFEVLYCGKV 220 TVTHKKAPSS 230 LIDDCMEKFS 240 LHEQQRLKIQ 250 GEQRGPDPGE 260 DLADLEVVVP 270 GSPGDCLPEE 280 ADGTDTHLGL 290 PAGASQPALT 300 SSRVCFPERI 310 LEDSGFDEQQ 320 EFRSRCSSVT 330 GVQRRVHEGS 340 QKSQPRRRHA 350 SAPSHVQPSD 360 SEKNRTMLFQ 370 VGRFEINLIS 380 PDTKSVVLEK 390 NFKDISSCSQ 400 GIKHVDHFGF 410 ICRESPEPGL 420 SQYICYVFQC 430 ASESLVDEVM 440 LTLKQAFSTA 450 AALQSAKTQI 460 KLCEACPMHS 470 LHKLCERIEG 480 LYPPRAKLVI 490 QRHLSSLTDN 500 EQADIFERVQ 510 KMKPVSDQEE 520 NELVILHLRQ 530 LCEAKQKTHV 540 HIGEGPSTIS 550 NSTIPENATS 560 SGRFKLDILK 570 NKAKRSLTSS 580 LENIFSRGAN 590 RMRGRLGSVD 600 SFERSNSLAS 610 EKDYSPGDSP 620 PGTPPASPPS 630 SAWQTFPEED 640 SDSPQFRRRA 650 HTFSHPPSST 660 KRKLNLQDGR 670 AQGVRSPLLR 680 QSSSEQCSNL 690 SSVRRMYKES 700 NSSSSLPSLH 710 TSFSAPSFTA 720 PSFLKSFYQN 730 SGRLSPQYEN 740 EIRQDTASES 750 SDGEGRKRTS 760 STCSNESLSV 770 GGTSVTPRRI 780 SWRQRIFLRV 790 ASPMNKSPSA 800 MQQQDGLDRN 810 ELLPLSPLSP 820 TMEEEPLVVF 830 LSGEDDPEKI 840 EERKKSKELR 850 SLWRKAIHQQ 860 ILLLRMEKEN 870 QKLEASRDEL 880 QSRKVKLDYE 890 EVGACQKEVL 900 ITWDKKLLNC 910 RAKIRCDMED 920 IHTLLKEGVP 930 KSRRGEIWQF 940 LALQYRLRHR 950 LPNKQQPPDI 960 SYKELLKQLT 970 AQQHAILVDL 980 GRTFPTHPYF 990 SVQLGPGQLS 1000 LFNLLKAYSL 1010 LDKEVGYCQG 1020 ISFVAGVLLL 1030 HMSEEQAFEM 1040 LKFLMYDLGF 1050 RKQYRPDMMS 1060 LQIQMYQLSR 1070 LLHDYHRDLY 1080 NHLEENEISP 1090 SLYAAPWFLT 1100 LFASQFSLGF 1110 VARVFDIIFL 1120 QGTEVIFKVA 1130 LSLLSSQETL 1140 IMECESFENI 1150 VEFLKNTLPD 1160 MNTSEMEKII 1170 TQVFEMDISK 1180 QLHAYEVEYH 1190 VLQDELQESS 1200 YSCEDSETLE 1210 KLERANSQLK 1220 RQNMDLLEKL 1230 QVAHTKIQAL 1240 ESNLENLLTR 1250 ETKMKSLIRT 1260 LEQEKMAYQK 1270 TVEQLRKLLP 1280 ADALVNCDLL 1290 LRDLNCNPNN KAKIGNKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Molecular Function GO:0005096 GTPase activator activity
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.