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Overview

Uniprot IDO60437
Protein NamePeriplakin
Gene NamePPL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1173 AKVVVQEKVREIVRP
1183 EIVRPDPKAESEVAN
12 FRKRNKGKYSPTVQT
1446 EKVTHTQKVVLQQDP
1498 EKAEVKEKVVLSESV
1520 EQEIQRLKSSLEEES
807 DYELEAEKLRSLLDL
940 VRKEVLKKVPDPVLE

Function

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling

Protein Sequence

10 MNSLFRKRNK 20 GKYSPTVQTR 30 SISNKELSEL 40 IEQLQKNADQ 50 VEKNIVDTEA 60 KMQSDLARLQ 70 EGRQPEHRDV 80 TLQKVLDSEK 90 LLYVLEADAA 100 IAKHMKHPQG 110 DMIAEDIRQL 120 KERVTNLRGK 130 HKQIYRLAVK 140 EVDPQVNWAA 150 LVEEKLDKLN 160 NQSFGTDLPL 170 VDHQVEEHNI 180 FHNEVKAIGP 190 HLAKDGDKEQ 200 NSELRAKYQK 210 LLAASQARQQ 220 HLSSLQDYMQ 230 RCTNELYWLD 240 QQAKGRMQYD 250 WSDRNLDYPS 260 RRRQYENFIN 270 RNLEAKEERI 280 NKLHSEGDQL 290 LAAEHPGRNS 300 IEAHMEAVHA 310 DWKEYLNLLI 320 CEESHLKYME 330 DYHQFHEDVK 340 DAQELLRKVD 350 SDLNQKYGPD 360 FKDRYQIELL 370 LRELDDQEKV 380 LDKYEDVVQG 390 LQKRGQQVVP 400 LKYRRETPLK 410 PIPVEALCDF 420 EGEQGLISRG 430 YSYTLQKNNG 440 ESWELMDSAG 450 NKLIAPAVCF 460 VIPPTDPEAL 470 ALADSLGSQY 480 RSVRQKAAGS 490 KRTLQQRYEV 500 LKTENPGDAS 510 DLQGRQLLAG 520 LDKVASDLDR 530 QEKAITGILR 540 PPLEQGRAVQ 550 DSAERAKDLK 560 NITNELLRIE 570 PEKTRSTAEG 580 EAFIQALPGS 590 GTTPLLRTRV 600 EDTNRKYEHL 610 LQLLDLAQEK 620 VDVANRLEKS 630 LQQSWELLAT 640 HENHLNQDDT 650 VPESSRVLDS 660 KGQELAAMAC 670 ELQAQKSLLG 680 EVEQNLQAAK 690 QCSSTLASRF 700 QEHCPDLERQ 710 EAEVHKLGQR 720 FNNLRQQVER 730 RAQSLQSAKA 740 AYEHFHRGHD 750 HVLQFLVSIP 760 SYEPQETDSL 770 SQMETKLKNQ 780 KNLLDEIASR 790 EQEVQKICAN 800 SQQYQQAVKD 810 YELEAEKLRS 820 LLDLENGRRS 830 HVSKRARLQS 840 PATKVKEEEA 850 ALAAKFTEVY 860 AINRQRLQNL 870 EFALNLLRQQ 880 PEVEVTHETL 890 QRNRPDSGVE 900 EAWKIRKELD 910 EETERRRQLE 920 NEVKSTQEEI 930 WTLRNQGPQE 940 SVVRKEVLKK 950 VPDPVLEESF 960 QQLQRTLAEE 970 QHKNQLLQEE 980 LEALQLQLRA 990 LEQETRDGGQ 1000 EYVVKEVLRI 1010 EPDRAQADEV 1020 LQLREELEAL 1030 RRQKGAREAE 1040 VLLLQQRVAA 1050 LAEEKSRAQE 1060 KVTEKEVVKL 1070 QNDPQLEAEY 1080 QQLQEDHQRQ 1090 DQLREKQEEE 1100 LSFLQDKLKR 1110 LEKERAMAEG 1120 KITVKEVLKV 1130 EKDAATEREV 1140 SDLTRQYEDE 1150 AAKARASQRE 1160 KTELLRKIWA 1170 LEEENAKVVV 1180 QEKVREIVRP 1190 DPKAESEVAN 1200 LRLELVEQER 1210 KYRGAEEQLR 1220 SYQSELEALR 1230 RRGPQVEVKE 1240 VTKEVIKYKT 1250 DPEMEKELQR 1260 LREEIVDKTR 1270 LIERCDLEIY 1280 QLKKEIQALK 1290 DTKPQVQTKE 1300 VVQEILQFQE 1310 DPQTKEEVAS 1320 LRAKLSEEQK 1330 KQVDLERERA 1340 SQEEQIARKE 1350 EELSRVKERV 1360 VQQEVVRYEE 1370 EPGLRAEASA 1380 FAESIDVELR 1390 QIDKLRAELR 1400 RLQRRRTELE 1410 RQLEELERER 1420 QARREAEREV 1430 QRLQQRLAAL 1440 EQEEAEAREK 1450 VTHTQKVVLQ 1460 QDPQQAREHA 1470 LLRLQLEEEQ 1480 HRRQLLEGEL 1490 ETLRRKLAAL 1500 EKAEVKEKVV 1510 LSESVQVEKG 1520 DTEQEIQRLK 1530 SSLEEESRSK 1540 RELDVEVSRL 1550 EARLSELEFH 1560 NSKSSKELDF 1570 LREENHKLQL 1580 ERQNLQLETR 1590 RLQSEINMAA 1600 TETRDLRNMT 1610 VADSGTNHDS 1620 RLWSLERELD 1630 DLKRLSKDKD 1640 LEIDELQKRL 1650 GSVAVKREQR 1660 ENHLRRSIVV 1670 IHPDTGRELS 1680 PEEAHRAGLI 1690 DWNMFVKLRS 1700 QECDWEEISV 1710 KGPNGESSVI 1720 HDRKSGKKFS 1730 IEEALQSGRL 1740 TPAQYDRYVN 1750 KDMSIQELAV LVSGQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030057 desmosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0031424 keratinization
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0042060 wound healing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.