Search Results
Overview
| Uniprot ID | O60443 |
|---|---|
| Protein Name | Gasdermin-E |
| Gene Name | GSDME |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | ETALGKVKLNLGGSS |
Function
Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856, PubMed:36607699). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430)
Protein Sequence
10
MFAKATRNFL
20
REVDADGDLI
30
AVSNLNDSDK
40
LQLLSLVTKK
50
KRFWCWQRPK
60
YQFLSLTLGD
70
VLIEDQFPSP
80
VVVESDFVKY
90
EGKFANHVSG
100
TLETALGKVK
110
LNLGGSSRVE
120
SQSSFGTLRK
130
QEVDLQQLIR
140
DSAERTINLR
150
NPVLQQVLEG
160
RNEVLCVLTQ
170
KITTMQKCVI
180
SEHMQVEEKC
190
GGIVGIQTKT
200
VQVSATEDGN
210
VTKDSNVVLE
220
IPAATTIAYG
230
VIELYVKLDG
240
QFEFCLLRGK
250
QGGFENKKRI
260
DSVYLDPLVF
270
REFAFIDMPD
280
AAHGISSQDG
290
PLSVLKQATL
300
LLERNFHPFA
310
ELPEPQQTAL
320
SDIFQAVLFD
330
DELLMVLEPV
340
CDDLVSGLSP
350
TVAVLGELKP
360
RQQQDLVAFL
370
QLVGCSLQGG
380
CPGPEDAGSK
390
QLFMTAYFLV
400
SALAEMPDSA
410
AALLGTCCKL
420
QIIPTLCHLL
430
RALSDDGVSD
440
LEDPTLTPLK
450
DTERFGIVQR
460
LFASADISLE
470
RLKSSVKAVI
480
LKDSKVFPLL
490
LCITLNGLCA
LGREHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:1901612 | cardiolipin binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0022829 | wide pore channel activity |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0002839 | positive regulation of immune response to tumor cell |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0012501 | programmed cell death |
| Biological Process | GO:0141201 | pyroptotic cell death |
| Biological Process | GO:0070269 | pyroptotic inflammatory response |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.