Search Results
Overview
| Uniprot ID | O60493 |
|---|---|
| Protein Name | Sorting nexin-3 |
| Gene Name | SNX3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 158 | DKSYTPSKIRHA*** |
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). Involved in regulation of neurite outgrowth in primary neurons (By similarity). Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0032009 | early phagosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| Molecular Function | GO:0010314 | phosphatidylinositol-5-phosphate binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:1905394 | retromer complex binding |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0046597 | host-mediated suppression of symbiont invasion |
| Biological Process | GO:0070676 | intralumenal vesicle formation |
| Biological Process | GO:0034499 | late endosome to Golgi transport |
| Biological Process | GO:0010324 | membrane invagination |
| Biological Process | GO:2000642 | negative regulation of early endosome to late endosome transport |
| Biological Process | GO:0050765 | negative regulation of phagocytosis |
| Biological Process | GO:0042177 | negative regulation of protein catabolic process |
| Biological Process | GO:0051224 | negative regulation of protein transport |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0022615 | protein to membrane docking |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0030111 | regulation of Wnt signaling pathway |
| Biological Process | GO:0009617 | response to bacterium |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.