Search Results

Overview

Uniprot IDO60502
Protein NameProtein O-GlcNAcase
Gene NameOGA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
597 SVVSVNCKGKDSEKI
599 VSVNCKGKDSEKIEE

Function

Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)

Protein Sequence

10 MVQKESQATL 20 EERESELSSN 30 PAASAGASLE 40 PPAAPAPGED 50 NPAGAGGAAV 60 AGAAGGARRF 70 LCGVVEGFYG 80 RPWVMEQRKE 90 LFRRLQKWEL 100 NTYLYAPKDD 110 YKHRMFWREM 120 YSVEEAEQLM 130 TLISAAREYE 140 IEFIYAISPG 150 LDITFSNPKE 160 VSTLKRKLDQ 170 VSQFGCRSFA 180 LLFDDIDHNM 190 CAADKEVFSS 200 FAHAQVSITN 210 EIYQYLGEPE 220 TFLFCPTEYC 230 GTFCYPNVSQ 240 SPYLRTVGEK 250 LLPGIEVLWT 260 GPKVVSKEIP 270 VESIEEVSKI 280 IKRAPVIWDN 290 IHANDYDQKR 300 LFLGPYKGRS 310 TELIPRLKGV 320 LTNPNCEFEA 330 NYVAIHTLAT 340 WYKSNMNGVR 350 KDVVMTDSED 360 STVSIQIKLE 370 NEGSDEDIET 380 DVLYSPQMAL 390 KLALTEWLQE 400 FGVPHQYSSR 410 QVAHSGAKAS 420 VVDGTPLVAA 430 PSLNATTVVT 440 TVYQEPIMSQ 450 GAALSGEPTT 460 LTKEEEKKQP 470 DEEPMDMVVE 480 KQEETDHKND 490 NQILSEIVEA 500 KMAEELKPMD 510 TDKESIAESK 520 SPEMSMQEDC 530 ISDIAPMQTD 540 EQTNKEQFVP 550 GPNEKPLYTA 560 EPVTLEDLQL 570 LADLFYLPYE 580 HGPKGAQMLR 590 EFQWLRANSS 600 VVSVNCKGKD 610 SEKIEEWRSR 620 AAKFEEMCGL 630 VMGMFTRLSN 640 CANRTILYDM 650 YSYVWDIKSI 660 MSMVKSFVQW 670 LGCRSHSSAQ 680 FLIGDQEPWA 690 FRGGLAGEFQ 700 RLLPIDGAND 710 LFFQPPPLTP 720 TSKVYTIRPY 730 FPKDEASVYK 740 ICREMYDDGV 750 GLPFQSQPDL 760 IGDKLVGGLL 770 SLSLDYCFVL 780 EDEDGICGYA 790 LGTVDVTPFI 800 KKCKISWIPF 810 MQEKYTKPNG 820 DKELSEAEKI 830 MLSFHEEQEV 840 LPETFLANFP 850 SLIKMDIHKK 860 VTDPSVAKSM 870 MACLLSSLKA 880 NGSRGAFCEV 890 RPDDKRILEF 900 YSKLGCFEIA 910 KMEGFPKDVV ILGRSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Molecular Function GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Molecular Function GO:0015929 hexosaminidase activity
Molecular Function GO:0004415 hyalurononglucosaminidase activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0006516 glycoprotein catabolic process
Biological Process GO:0009100 glycoprotein metabolic process
Biological Process GO:0006044 N-acetylglucosamine metabolic process
Biological Process GO:0006517 protein deglycosylation
Biological Process GO:0006493 protein O-linked glycosylation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.