Search Results
Overview
| Uniprot ID | O60504 |
|---|---|
| Protein Name | Vinexin |
| Gene Name | SORBS3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 388 | KRKAARLKFDFQAQS |
| 415 | YIHKEVDKNWLEGEH |
Function
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain
Protein Sequence
10
MQGPPRSLRA
20
GLSLDDFIPG
30
HLQSHIGSSS
40
RGTRVPVIRN
50
GGSNTLNFQF
60
HDPAPRTVCN
70
GGYTPRRDAS
80
QHPDPAWYQT
90
WPGPGSKPSA
100
STKIPASQHT
110
QNWSATWTKD
120
SKRRDKRWVK
130
YEGIGPVDES
140
GMPIAPRSSV
150
DRPRDWYRRM
160
FQQIHRKMPD
170
LQLDWTFEEP
180
PRDPRHLGAQ
190
QRPAHRPGPA
200
TSSSGRSWDH
210
SEELPRSTFN
220
YRPGAFSTVL
230
QPSNQVLRRR
240
EKVDNVWTEE
250
SWNQFLQELE
260
TGQRPKKPLV
270
DDPGEKPSQP
280
IEVLLERELA
290
ELSAELDKDL
300
RAIETRLPSP
310
KSSPAPRRAP
320
EQRPPAGPAS
330
AWSSSYPHAP
340
YLGSARSLSP
350
HKMADGGSPF
360
LGRRDFVYPS
370
STRDPSASNG
380
GGSPARREEK
390
KRKAARLKFD
400
FQAQSPKELT
410
LQKGDIVYIH
420
KEVDKNWLEG
430
EHHGRLGIFP
440
ANYVEVLPAD
450
EIPKPIKPPT
460
YQVLEYGEAV
470
AQYTFKGDLE
480
VELSFRKGEH
490
ICLIRKVNEN
500
WYEGRITGTG
510
RQGIFPASYV
520
QVSREPRLRL
530
CDDGPQLPTS
540
PRLTAAARSA
550
RHPSSPSALR
560
SPADPIDLGG
570
QTSPRRTGFS
580
FPTQEPRPQT
590
QNLGTPGPAL
600
SHSRGPSHPL
610
DLGTSSPNTS
620
QIHWTPYRAM
630
YQYRPQNEDE
640
LELREGDRVD
650
VMQQCDDGWF
660
VGVSRRTQKF
670
GTFPGNYVAP
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030055 | cell-substrate junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0017166 | vinculin binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0031589 | cell-substrate adhesion |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0051495 | positive regulation of cytoskeleton organization |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.