Search Results

Overview

Uniprot IDO60506
Protein NameHeterogeneous nuclear ribonucleoprotein Q
Gene NameSYNCRIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 AFLCGVMKTYRQREK
221 EAAQEAVKLYNNHEI
252 LFVGSIPKSKTKEQI
256 SIPKSKTKEQILEEF
338 PEVMAKVKVLFVRNL
363 KAFSQFGKLERVKKL
371 LERVKKLKDYAFIHF
566 GNVGGKRKADGYNQP
576 GYNQPDSKRRQTNNQ

Function

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; does not seem to be essential for GAIT complex function

Protein Sequence

10 MATEHVNGNG 20 TEEPMDTTSA 30 VIHSENFQTL 40 LDAGLPQKVA 50 EKLDEIYVAG 60 LVAHSDLDER 70 AIEALKEFNE 80 DGALAVLQQF 90 KDSDLSHVQN 100 KSAFLCGVMK 110 TYRQREKQGT 120 KVADSSKGPD 130 EAKIKALLER 140 TGYTLDVTTG 150 QRKYGGPPPD 160 SVYSGQQPSV 170 GTEIFVGKIP 180 RDLFEDELVP 190 LFEKAGPIWD 200 LRLMMDPLTG 210 LNRGYAFVTF 220 CTKEAAQEAV 230 KLYNNHEIRS 240 GKHIGVCISV 250 ANNRLFVGSI 260 PKSKTKEQIL 270 EEFSKVTEGL 280 TDVILYHQPD 290 DKKKNRGFCF 300 LEYEDHKTAA 310 QARRRLMSGK 320 VKVWGNVGTV 330 EWADPIEDPD 340 PEVMAKVKVL 350 FVRNLANTVT 360 EEILEKAFSQ 370 FGKLERVKKL 380 KDYAFIHFDE 390 RDGAVKAMEE 400 MNGKDLEGEN 410 IEIVFAKPPD 420 QKRKERKAQR 430 QAAKNQMYDD 440 YYYYGPPHMP 450 PPTRGRGRGG 460 RGGYGYPPDY 470 YGYEDYYDYY 480 GYDYHNYRGG 490 YEDPYYGYED 500 FQVGARGRGG 510 RGARGAAPSR 520 GRGAAPPRGR 530 AGYSQRGGPG 540 SARGVRGARG 550 GAQQQRGRGV 560 RGARGGRGGN 570 VGGKRKADGY 580 NQPDSKRRQT 590 NNQNWGSQPI 600 AQQPLQGGDH 610 SGNYGYKSEN 620 QEFYQDTFGQ QWK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0070937 CRD-mediated mRNA stability complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0097452 GAIT complex
Cellular Component GO:0071204 histone pre-mRNA 3'end processing complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0048027 mRNA 5'-UTR binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0071346 cellular response to type II interferon
Biological Process GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway
Biological Process GO:0070934 CRD-mediated mRNA stabilization
Biological Process GO:0016556 mRNA modification
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:1901194 negative regulation of formation of translation preinitiation complex
Biological Process GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0006396 RNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.