Search Results

Overview

Uniprot IDO60508
Protein NamePre-mRNA-processing factor 17
Gene NameCDC40
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
174 VFETGQKKTEKRKKF
222 ELDEITAKRQKKGKQ

Function

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177)

Protein Sequence

10 MSAAIAALAA 20 SYGSGSGSES 30 DSDSESSRCP 40 LPAADSLMHL 50 TKSPSSKPSL 60 AVAVDSAPEV 70 AVKEDLETGV 80 HLDPAVKEVQ 90 YNPTYETMFA 100 PEFGPENPFR 110 TQQMAAPRNM 120 LSGYAEPAHI 130 NDFMFEQQRR 140 TFATYGYALD 150 PSLDNHQVSA 160 KYIGSVEEAE 170 KNQGLTVFET 180 GQKKTEKRKK 190 FKENDASNID 200 GFLGPWAKYV 210 DEKDVAKPSE 220 EEQKELDEIT 230 AKRQKKGKQE 240 EEKPGEEKTI 250 LHVKEMYDYQ 260 GRSYLHIPQD 270 VGVNLRSTMP 280 PEKCYLPKKQ 290 IHVWSGHTKG 300 VSAVRLFPLS 310 GHLLLSCSMD 320 CKIKLWEVYG 330 ERRCLRTFIG 340 HSKAVRDICF 350 NTAGTQFLSA 360 AYDRYLKLWD 370 TETGQCISRF 380 TNRKVPYCVK 390 FNPDEDKQNL 400 FVAGMSDKKI 410 VQWDIRSGEI 420 VQEYDRHLGA 430 VNTIVFVDEN 440 RRFVSTSDDK 450 SLRVWEWDIP 460 VDFKYIAEPS 470 MHSMPAVTLS 480 PNGKWLACQS 490 MDNQILIFGA 500 QNRFRLNKKK 510 IFKGHMVAGY 520 ACQVDFSPDM 530 SYVISGDGNG 540 KLNIWDWKTT 550 KLYSRFKAHD 560 KVCIGAVWHP 570 HETSKVITCG WDGLIKLWD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:1990403 embryonic brain development
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.