Search Results

Overview

Uniprot IDO60522
Protein NameTudor domain-containing protein 6
Gene NameTDRD6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
826 NTLACLAKRTVNRQW
901 NPFVWDVKAIQAFNE

Function

Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity)

Protein Sequence

10 MCSTPGMPAP 20 GASLALRVSF 30 VDVHPDVIPV 40 QLWGLVGERR 50 GEYLRLSREI 60 QEAAATRGQW 70 ALGSASASPG 80 ELCLVQVGLL 90 WHRCRVVSRQ 100 AQESRVFLLD 110 EGRTITAGAG 120 SLAPGRREFF 130 NLPSEVLGCV 140 LAGLVPAGCG 150 AGSGEPPQHW 160 PADAVDFLSN 170 LQGKEVHGCV 180 LDVLLLHRLV 190 LLEVPDVFQQ 200 MRELGLARRV 210 PDSLFRSLLE 220 RYLTAATASV 230 GSGVPVLSRV 240 PLKQKQPGLD 250 YFYPQLQLGV 260 TEAVVITQVC 270 HPHRIHCQLR 280 SVSQEIHRLS 290 ESMAQVYRGS 300 TGTGDENSTS 310 ATWEEREESP 320 DKPGSPCASC 330 GLDGHWYRAL 340 LLETFRPQRC 350 AQVLHVDYGR 360 KELVSCSSLR 370 YLLPEYFRMP 380 VVTYPCALYG 390 LWDGGRGWSR 400 SQVGDLKTLI 410 LGKAVNAKIE 420 FYCSFEHVYY 430 VSLYGEDGIN 440 LNRVFGVQSC 450 CLADRVLQSQ 460 ATEEEEPETS 470 QSQSPAEEVD 480 EEISLPALRS 490 IRLKMNAFYD 500 AQVEFVKNPS 510 EFWIRLRKHN 520 VTFSKLMRRM 530 CGFYSSASKL 540 DGVVLKPEPD 550 DLCCVKWKEN 560 GYYRAIVTKL 570 DDKSVDVFLV 580 DRGNSENVDW 590 YDVRMLLPQF 600 RQLPILAVKC 610 TLADIWPLGK 620 TWSQEAVSFF 630 KKTVLHKELV 640 IHILDKQDHQ 650 YVIEILDESR 660 TGEENISKVI 670 AQAGYAKYQE 680 FETKENILVN 690 AHSPGHVSNH 700 FTTESNKIPF 710 AKTGEGEQKA 720 KRENKTTSVS 730 KALSDTTVVT 740 NGSTELVVQE 750 KVKRASVYFP 760 LMQNCLEIKP 770 GSSSKGELEV 780 GSTVEVRVSY 790 VENPGYFWCQ 800 LTRNIQGLKT 810 LMSDIQYYCK 820 NTAAPHQRNT 830 LACLAKRTVN 840 RQWSRALISG 850 IQSVEHVNVT 860 FVDYGDREMV 870 SVKNIYSISE 880 EFLKVKAQAF 890 RCSLYNLIQP 900 VGQNPFVWDV 910 KAIQAFNEFI 920 DNAWQKNLEL 930 KCTIFALASI 940 NEELFNIVDL 950 LTPFQSACHF 960 LVEKRLARPV 970 KLQKPLESSV 980 QLHSYFYSTH 990 DMKIGSEELV 1000 YITHIDDPWT 1010 FYCQLARNAN 1020 ILEQLSCSIT 1030 QLSKVLLNLK 1040 TSPLNPGTLC 1050 LAKYTDGNWY 1060 RGIVIEKEPK 1070 KVFFVDFGNI 1080 YVVTSDDLLP 1090 IPSDAYDVLL 1100 LPMQAVRCSL 1110 SDIPDHIPEE 1120 VVVWFQETIL 1130 DKSLKALVVA 1140 KDPDGTLIIE 1150 LYGDNIQISA 1160 SINKKLGLLS 1170 YKDRIRKKES 1180 EVLCSTTETL 1190 EEKNENMKLP 1200 CTEYLSKSVG 1210 YKLPNKEILE 1220 ESYKPQINSS 1230 YKELKLLQSL 1240 TKTNLVTQYQ 1250 DSVGNKNSQV 1260 FPLTTEKKEE 1270 ISAETPLKTA 1280 RVEATLSERK 1290 IGDSCDKDLP 1300 LKFCEFPQKT 1310 IMPGFKTTVY 1320 VSHINDLSDF 1330 YVQLIEDEAE 1340 ISHLSERLNS 1350 VKTRPEYYVG 1360 PPLQRGDMIC 1370 AVFPEDNLWY 1380 RAVIKEQQPN 1390 DLLSVQFIDY 1400 GNVSVVHTNK 1410 IGRLDLVNAI 1420 LPGLCIHCSL 1430 QGFEVPDNKN 1440 SKKMMHYFSQ 1450 RTSEAAIRCE 1460 FVKFQDRWEV 1470 ILADEHGIIA 1480 DDMISRYALS 1490 EKSQVELSTQ 1500 VIKSASSKSV 1510 NKSDIDTSVF 1520 LNWYNPEKKM 1530 IRAYATVIDG 1540 PEYFWCQFAD 1550 TEKLQCLEVE 1560 VQTAGEQVAD 1570 RRNCIPCPYI 1580 GDPCIVRYRE 1590 DGHYYRALIT 1600 NICEDYLVSV 1610 RLVDFGNIED 1620 CVDPKALWAI 1630 PSELLSVPMQ 1640 AFPCCLSGFN 1650 ISEGLCSQEG 1660 NDYFYEIITE 1670 DVLEITILEI 1680 RRDVCDIPLA 1690 IVDLKSKGKS 1700 INEKMEKYSK 1710 TGIKSALPYE 1720 NIDSEIKQTL 1730 GSYNLDVGLK 1740 KLSNKAVQNK 1750 IYMEQQTDEL 1760 AEITEKDVNI 1770 IGTKPSNFRD 1780 PKTDNICEGF 1790 ENPCKDKIDT 1800 EELEGELECH 1810 LVDKAEFDDK 1820 YLITGFNTLL 1830 PHANETKEIL 1840 ELNSLEVPLS 1850 PDDESKEFLE 1860 LESIELQNSL 1870 VVDEEKGELS 1880 PVPPNVPLSQ 1890 ECVTKGAMEL 1900 FTLQLPLSCE 1910 AEKQPELELP 1920 TAQLPLDDKM 1930 DPLSLGVSQK 1940 AQESMCTEDM 1950 RKSSCVESFD 1960 DQRRMSLHLH 1970 GADCDPKTQN 1980 EMNICEEEFV 1990 EYKNRDAISA 2000 LMPLFSEEES 2010 SDGSKHNNGL 2020 PDHISAQLQN 2030 TYTLKAFTVG 2040 SKCVVWSSLR 2050 NTWSKCEILE 2060 TAEEGTRVLN 2070 LSNGMEEIVN 2080 PENVWNGIPK 2090 LDKSPPEKRG LEVMEI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0033391 chromatoid body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0043186 P granule
Biological Process GO:0030719 P granule organization
Biological Process GO:0034587 piRNA processing
Biological Process GO:0007283 spermatogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.