Overview
| Uniprot ID | O60522 |
| Protein Name | Tudor domain-containing protein 6 |
| Gene Name | TDRD6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 826 |
NTLACLAKRTVNRQW |
| 901 |
NPFVWDVKAIQAFNE |
Function
Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity)
Protein Sequence
10
MCSTPGMPAP
20
GASLALRVSF
30
VDVHPDVIPV
40
QLWGLVGERR
50
GEYLRLSREI
60
QEAAATRGQW
70
ALGSASASPG
80
ELCLVQVGLL
90
WHRCRVVSRQ
100
AQESRVFLLD
110
EGRTITAGAG
120
SLAPGRREFF
130
NLPSEVLGCV
140
LAGLVPAGCG
150
AGSGEPPQHW
160
PADAVDFLSN
170
LQGKEVHGCV
180
LDVLLLHRLV
190
LLEVPDVFQQ
200
MRELGLARRV
210
PDSLFRSLLE
220
RYLTAATASV
230
GSGVPVLSRV
240
PLKQKQPGLD
250
YFYPQLQLGV
260
TEAVVITQVC
270
HPHRIHCQLR
280
SVSQEIHRLS
290
ESMAQVYRGS
300
TGTGDENSTS
310
ATWEEREESP
320
DKPGSPCASC
330
GLDGHWYRAL
340
LLETFRPQRC
350
AQVLHVDYGR
360
KELVSCSSLR
370
YLLPEYFRMP
380
VVTYPCALYG
390
LWDGGRGWSR
400
SQVGDLKTLI
410
LGKAVNAKIE
420
FYCSFEHVYY
430
VSLYGEDGIN
440
LNRVFGVQSC
450
CLADRVLQSQ
460
ATEEEEPETS
470
QSQSPAEEVD
480
EEISLPALRS
490
IRLKMNAFYD
500
AQVEFVKNPS
510
EFWIRLRKHN
520
VTFSKLMRRM
530
CGFYSSASKL
540
DGVVLKPEPD
550
DLCCVKWKEN
560
GYYRAIVTKL
570
DDKSVDVFLV
580
DRGNSENVDW
590
YDVRMLLPQF
600
RQLPILAVKC
610
TLADIWPLGK
620
TWSQEAVSFF
630
KKTVLHKELV
640
IHILDKQDHQ
650
YVIEILDESR
660
TGEENISKVI
670
AQAGYAKYQE
680
FETKENILVN
690
AHSPGHVSNH
700
FTTESNKIPF
710
AKTGEGEQKA
720
KRENKTTSVS
730
KALSDTTVVT
740
NGSTELVVQE
750
KVKRASVYFP
760
LMQNCLEIKP
770
GSSSKGELEV
780
GSTVEVRVSY
790
VENPGYFWCQ
800
LTRNIQGLKT
810
LMSDIQYYCK
820
NTAAPHQRNT
830
LACLAKRTVN
840
RQWSRALISG
850
IQSVEHVNVT
860
FVDYGDREMV
870
SVKNIYSISE
880
EFLKVKAQAF
890
RCSLYNLIQP
900
VGQNPFVWDV
910
KAIQAFNEFI
920
DNAWQKNLEL
930
KCTIFALASI
940
NEELFNIVDL
950
LTPFQSACHF
960
LVEKRLARPV
970
KLQKPLESSV
980
QLHSYFYSTH
990
DMKIGSEELV
1000
YITHIDDPWT
1010
FYCQLARNAN
1020
ILEQLSCSIT
1030
QLSKVLLNLK
1040
TSPLNPGTLC
1050
LAKYTDGNWY
1060
RGIVIEKEPK
1070
KVFFVDFGNI
1080
YVVTSDDLLP
1090
IPSDAYDVLL
1100
LPMQAVRCSL
1110
SDIPDHIPEE
1120
VVVWFQETIL
1130
DKSLKALVVA
1140
KDPDGTLIIE
1150
LYGDNIQISA
1160
SINKKLGLLS
1170
YKDRIRKKES
1180
EVLCSTTETL
1190
EEKNENMKLP
1200
CTEYLSKSVG
1210
YKLPNKEILE
1220
ESYKPQINSS
1230
YKELKLLQSL
1240
TKTNLVTQYQ
1250
DSVGNKNSQV
1260
FPLTTEKKEE
1270
ISAETPLKTA
1280
RVEATLSERK
1290
IGDSCDKDLP
1300
LKFCEFPQKT
1310
IMPGFKTTVY
1320
VSHINDLSDF
1330
YVQLIEDEAE
1340
ISHLSERLNS
1350
VKTRPEYYVG
1360
PPLQRGDMIC
1370
AVFPEDNLWY
1380
RAVIKEQQPN
1390
DLLSVQFIDY
1400
GNVSVVHTNK
1410
IGRLDLVNAI
1420
LPGLCIHCSL
1430
QGFEVPDNKN
1440
SKKMMHYFSQ
1450
RTSEAAIRCE
1460
FVKFQDRWEV
1470
ILADEHGIIA
1480
DDMISRYALS
1490
EKSQVELSTQ
1500
VIKSASSKSV
1510
NKSDIDTSVF
1520
LNWYNPEKKM
1530
IRAYATVIDG
1540
PEYFWCQFAD
1550
TEKLQCLEVE
1560
VQTAGEQVAD
1570
RRNCIPCPYI
1580
GDPCIVRYRE
1590
DGHYYRALIT
1600
NICEDYLVSV
1610
RLVDFGNIED
1620
CVDPKALWAI
1630
PSELLSVPMQ
1640
AFPCCLSGFN
1650
ISEGLCSQEG
1660
NDYFYEIITE
1670
DVLEITILEI
1680
RRDVCDIPLA
1690
IVDLKSKGKS
1700
INEKMEKYSK
1710
TGIKSALPYE
1720
NIDSEIKQTL
1730
GSYNLDVGLK
1740
KLSNKAVQNK
1750
IYMEQQTDEL
1760
AEITEKDVNI
1770
IGTKPSNFRD
1780
PKTDNICEGF
1790
ENPCKDKIDT
1800
EELEGELECH
1810
LVDKAEFDDK
1820
YLITGFNTLL
1830
PHANETKEIL
1840
ELNSLEVPLS
1850
PDDESKEFLE
1860
LESIELQNSL
1870
VVDEEKGELS
1880
PVPPNVPLSQ
1890
ECVTKGAMEL
1900
FTLQLPLSCE
1910
AEKQPELELP
1920
TAQLPLDDKM
1930
DPLSLGVSQK
1940
AQESMCTEDM
1950
RKSSCVESFD
1960
DQRRMSLHLH
1970
GADCDPKTQN
1980
EMNICEEEFV
1990
EYKNRDAISA
2000
LMPLFSEEES
2010
SDGSKHNNGL
2020
PDHISAQLQN
2030
TYTLKAFTVG
2040
SKCVVWSSLR
2050
NTWSKCEILE
2060
TAEEGTRVLN
2070
LSNGMEEIVN
2080
PENVWNGIPK
2090
LDKSPPEKRG
LEVMEI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0033391 |
chromatoid body |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0043186 |
P granule |
| Biological Process |
GO:0030719 |
P granule organization |
| Biological Process |
GO:0034587 |
piRNA processing |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.