Search Results
Overview
| Uniprot ID | O60551 |
|---|---|
| Protein Name | Glycylpeptide N-tetradecanoyltransferase 2 |
| Gene Name | NMT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 82 | IKIQQPSKNPSVPMQ |
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017)
Protein Sequence
10
MAEDSESAAS
20
QQSLELDDQD
30
TCGIDGDNEE
40
ETEHAKGSPG
50
GYLGAKKKKK
60
KQKRKKEKPN
70
SGGTKSDSAS
80
DSQEIKIQQP
90
SKNPSVPMQK
100
LQDIQRAMEL
110
LSACQGPARN
120
IDEAAKHRYQ
130
FWDTQPVPKL
140
DEVITSHGAI
150
EPDKDNVRQE
160
PYSLPQGFMW
170
DTLDLSDAEV
180
LKELYTLLNE
190
NYVEDDDNMF
200
RFDYSPEFLL
210
WALRPPGWLL
220
QWHCGVRVSS
230
NKKLVGFISA
240
IPANIRIYDS
250
VKKMVEINFL
260
CVHKKLRSKR
270
VAPVLIREIT
280
RRVNLEGIFQ
290
AVYTAGVVLP
300
KPIATCRYWH
310
RSLNPRKLVE
320
VKFSHLSRNM
330
TLQRTMKLYR
340
LPDVTKTSGL
350
RPMEPKDIKS
360
VRELINTYLK
370
QFHLAPVMDE
380
EEVAHWFLPR
390
EHIIDTFVVE
400
SPNGKLTDFL
410
SFYTLPSTVM
420
HHPAHKSLKA
430
AYSFYNIHTE
440
TPLLDLMSDA
450
LILAKSKGFD
460
VFNALDLMEN
470
KTFLEKLKFG
480
IGDGNLQYYL
490
YNWRCPGTDS
EKVGLVLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0043657 | host cell |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity |
| Molecular Function | GO:0018030 | peptidyl-lysine N6-myristoyltransferase activity |
| Biological Process | GO:0075733 | intracellular transport of virus |
| Biological Process | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation |
| Biological Process | GO:0072657 | protein localization to membrane |
| Biological Process | GO:0022400 | regulation of opsin-mediated signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.