Overview
| Uniprot ID | O60583 |
|---|
| Protein Name | Cyclin-T2 |
|---|
| Gene Name | CCNT2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 438 |
PQKMSLDKYREKRKL |
| 633 |
ASHNHHSKMSKSSKS |
Function
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity)
Protein Sequence
10
MASGRGASSR
20
WFFTREQLEN
30
TPSRRCGVEA
40
DKELSCRQQA
50
ANLIQEMGQR
60
LNVSQLTINT
70
AIVYMHRFYM
80
HHSFTKFNKN
90
IISSTALFLA
100
AKVEEQARKL
110
EHVIKVAHAC
120
LHPLEPLLDT
130
KCDAYLQQTQ
140
ELVILETIML
150
QTLGFEITIE
160
HPHTDVVKCT
170
QLVRASKDLA
180
QTSYFMATNS
190
LHLTTFCLQY
200
KPTVIACVCI
210
HLACKWSNWE
220
IPVSTDGKHW
230
WEYVDPTVTL
240
ELLDELTHEF
250
LQILEKTPNR
260
LKKIRNWRAN
270
QAARKPKVDG
280
QVSETPLLGS
290
SLVQNSILVD
300
SVTGVPTNPS
310
FQKPSTSAFP
320
APVPLNSGNI
330
SVQDSHTSDN
340
LSMLATGMPS
350
TSYGLSSHQE
360
WPQHQDSART
370
EQLYSQKQET
380
SLSGSQYNIN
390
FQQGPSISLH
400
SGLHHRPDKI
410
SDHSSVKQEY
420
THKAGSSKHH
430
GPISTTPGII
440
PQKMSLDKYR
450
EKRKLETLDL
460
DVRDHYIAAQ
470
VEQQHKQGQS
480
QAASSSSVTS
490
PIKMKIPIAN
500
TEKYMADKKE
510
KSGSLKLRIP
520
IPPTDKSASK
530
EELKMKIKVS
540
SSERHSSSDE
550
GSGKSKHSSP
560
HISRDHKEKH
570
KEHPSSRHHT
580
SSHKHSHSHS
590
GSSSGGSKHS
600
ADGIPPTVLR
610
SPVGLSSDGI
620
SSSSSSSRKR
630
LHVNDASHNH
640
HSKMSKSSKS
650
SGSSSSSSSS
660
VKQYISSHNS
670
VFNHPLPPPP
680
PVTYQVGYGH
690
LSTLVKLDKK
700
PVETNGPDAN
710
HEYSTSSQHM
720
DYKDTFDMLD
730
SLLSAQGMNM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008024 |
cyclin/CDK positive transcription elongation factor complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0097322 |
7SK snRNA binding |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0061575 |
cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0070063 |
RNA polymerase binding |
| Molecular Function |
GO:0001223 |
transcription coactivator binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0019085 |
early viral transcription |
| Biological Process |
GO:0019086 |
late viral transcription |
| Biological Process |
GO:0032786 |
positive regulation of DNA-templated transcription, elongation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0032968 |
positive regulation of transcription elongation by RNA polymerase II |
| Biological Process |
GO:0000079 |
regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process |
GO:0051147 |
regulation of muscle cell differentiation |
| Biological Process |
GO:0007519 |
skeletal muscle tissue development |
| Biological Process |
GO:0006366 |
transcription by RNA polymerase II |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.