Overview
| Uniprot ID | O60635 |
|---|
| Protein Name | Tetraspanin-1 |
|---|
| Gene Name | TSPAN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
QVWNTTMKGLKCCGF |
| 148 |
NTTMKGLKCCGFTNY |
Function
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:30066932, PubMed:30291375). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK (PubMed:30291375). Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (PubMed:21836059)
Protein Sequence
10
MQCFSFIKTM
20
MILFNLLIFL
30
CGAALLAVGI
40
WVSIDGASFL
50
KIFGPLSSSA
60
MQFVNVGYFL
70
IAAGVVVFAL
80
GFLGCYGAKT
90
ESKCALVTFF
100
FILLLIFIAE
110
VAAAVVALVY
120
TTMAEHFLTL
130
LVVPAIKKDY
140
GSQEDFTQVW
150
NTTMKGLKCC
160
GFTNYTDFED
170
SPYFKENSAF
180
PPFCCNDNVT
190
NTANETCTKQ
200
KAHDQKVEGC
210
FNQLLYDIRT
220
NAVTVGGVAA
230
GIGGLELAAM
240
IVSMYLYCNL
Q
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0031982 |
vesicle |
| Biological Process |
GO:0050821 |
protein stabilization |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.