Overview
| Uniprot ID | O60656 |
|---|
| Protein Name | UDP-glucuronosyltransferase 1A9 |
|---|
| Gene Name | UGT1A9 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 132 |
RSLFKDKKLVEYLKE |
| 47 |
TMRSVVEKLILRGHE |
| 99 |
AFAHAQWKAQVRSIY |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:15472229, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173, PubMed:15231852, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP) (PubMed:15231852, PubMed:38211441). Glucuronates the phytochemical ferulic acid efficiently at both the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212)
Protein Sequence
10
MACTGWTSPL
20
PLCVCLLLTC
30
GFAEAGKLLV
40
VPMDGSHWFT
50
MRSVVEKLIL
60
RGHEVVVVMP
70
EVSWQLGRSL
80
NCTVKTYSTS
90
YTLEDLDREF
100
KAFAHAQWKA
110
QVRSIYSLLM
120
GSYNDIFDLF
130
FSNCRSLFKD
140
KKLVEYLKES
150
SFDAVFLDPF
160
DNCGLIVAKY
170
FSLPSVVFAR
180
GILCHYLEEG
190
AQCPAPLSYV
200
PRILLGFSDA
210
MTFKERVRNH
220
IMHLEEHLLC
230
HRFFKNALEI
240
ASEILQTPVT
250
EYDLYSHTSI
260
WLLRTDFVLD
270
YPKPVMPNMI
280
FIGGINCHQG
290
KPLPMEFEAY
300
INASGEHGIV
310
VFSLGSMVSE
320
IPEKKAMAIA
330
DALGKIPQTV
340
LWRYTGTRPS
350
NLANNTILVK
360
WLPQNDLLGH
370
PMTRAFITHA
380
GSHGVYESIC
390
NGVPMVMMPL
400
FGDQMDNAKR
410
METKGAGVTL
420
NVLEMTSEDL
430
ENALKAVIND
440
KSYKENIMRL
450
SSLHKDRPVE
460
PLDLAVFWVE
470
FVMRHKGAPH
480
LRPAAHDLTW
490
YQYHSLDVIG
500
FLLAVVLTVA
510
FITFKCCAYG
520
YRKCLGKKGR
530
VKKAHKSKTH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0001972 |
retinoic acid binding |
| Molecular Function |
GO:0008194 |
UDP-glycosyltransferase activity |
| Biological Process |
GO:0071385 |
cellular response to glucocorticoid stimulus |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0051552 |
flavone metabolic process |
| Biological Process |
GO:0009812 |
flavonoid metabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0045922 |
negative regulation of fatty acid metabolic process |
| Biological Process |
GO:0042573 |
retinoic acid metabolic process |
| Biological Process |
GO:0016125 |
sterol metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.