Search Results

Overview

Uniprot IDO60664
Protein NamePerilipin-3
Gene NamePLIN3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
122 EKVLADTKELVSSKV
128 TKELVSSKVSGAQEM
164 AVQSGVDKTKSVVTG
166 QSGVDKTKSVVTGGV
257 AYEHSLGKLRATKQR
65 TVCDAAEKGVRTLTA
84 GAQPILSKLEPQIAS

Function

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177)

Protein Sequence

10 MSADGAEADG 20 STQVTVEEPV 30 QQPSVVDRVA 40 SMPLISSTCD 50 MVSAAYASTK 60 ESYPHIKTVC 70 DAAEKGVRTL 80 TAAAVSGAQP 90 ILSKLEPQIA 100 SASEYAHRGL 110 DKLEENLPIL 120 QQPTEKVLAD 130 TKELVSSKVS 140 GAQEMVSSAK 150 DTVATQLSEA 160 VDATRGAVQS 170 GVDKTKSVVT 180 GGVQSVMGSR 190 LGQMVLSGVD 200 TVLGKSEEWA 210 DNHLPLTDAE 220 LARIATSLDG 230 FDVASVQQQR 240 QEQSYFVRLG 250 SLSERLRQHA 260 YEHSLGKLRA 270 TKQRAQEALL 280 QLSQVLSLME 290 TVKQGVDQKL 300 VEGQEKLHQM 310 WLSWNQKQLQ 320 GPEKEPPKPE 330 QVESRALTMF 340 RDIAQQLQAT 350 CTSLGSSIQG 360 LPTNVKDQVQ 370 QARRQVEDLQ 380 ATFSSIHSFQ 390 DLSSSILAQS 400 RERVASAREA 410 LDHMVEYVAQ 420 NTPVTWLVGP 430 FAPGITEKAP EEKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0016020 membrane
Cellular Component GO:0030133 transport vesicle
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:1905691 lipid droplet disassembly
Biological Process GO:0019915 lipid storage
Biological Process GO:0010890 positive regulation of triglyceride storage
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.