Search Results

Overview

Uniprot IDO60701
Protein NameUDP-glucose 6-dehydrogenase
Gene NameUGDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 KGRAADLKYIEACAR
124 VQNSNGYKIVTEKST
129 GYKIVTEKSTVPVRA
207 EHWVPREKILTTNTW
279 FGGSCFQKDVLNLVY
329 LFNTVTDKKIAILGF
370 HLHIYDPKVPREQIV
431 DYERIHKKMLKPAFI
481 APSGEIPKFSLQDPP
490 SLQDPPNKKPKV***
491 LQDPPNKKPKV****
493 DPPNKKPKV******
58 PIYEPGLKEVVESCR
6 **MFEIKKICCIGAG

Function

Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716)

Protein Sequence

10 MFEIKKICCI 20 GAGYVGGPTC 30 SVIAHMCPEI 40 RVTVVDVNES 50 RINAWNSPTL 60 PIYEPGLKEV 70 VESCRGKNLF 80 FSTNIDDAIK 90 EADLVFISVN 100 TPTKTYGMGK 110 GRAADLKYIE 120 ACARRIVQNS 130 NGYKIVTEKS 140 TVPVRAAESI 150 RRIFDANTKP 160 NLNLQVLSNP 170 EFLAEGTAIK 180 DLKNPDRVLI 190 GGDETPEGQR 200 AVQALCAVYE 210 HWVPREKILT 220 TNTWSSELSK 230 LAANAFLAQR 240 ISSINSISAL 250 CEATGADVEE 260 VATAIGMDQR 270 IGNKFLKASV 280 GFGGSCFQKD 290 VLNLVYLCEA 300 LNLPEVARYW 310 QQVIDMNDYQ 320 RRRFASRIID 330 SLFNTVTDKK 340 IAILGFAFKK 350 DTGDTRESSS 360 IYISKYLMDE 370 GAHLHIYDPK 380 VPREQIVVDL 390 SHPGVSEDDQ 400 VSRLVTISKD 410 PYEACDGAHA 420 VVICTEWDMF 430 KELDYERIHK 440 KMLKPAFIFD 450 GRRVLDGLHN 460 ELQTIGFQIE 470 TIGKKVSSKR 480 IPYAPSGEIP 490 KFSLQDPPNK KPKV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0003979 UDP-glucose 6-dehydrogenase activity
Biological Process GO:0050650 chondroitin sulfate proteoglycan biosynthetic process
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0006024 glycosaminoglycan biosynthetic process
Biological Process GO:0015012 heparan sulfate proteoglycan biosynthetic process
Biological Process GO:0048666 neuron development
Biological Process GO:0034214 protein hexamerization
Biological Process GO:0006065 UDP-glucuronate biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.