Search Results

Overview

Uniprot ID	O60716
Protein Name	Catenin delta-1
Gene Name	CTNND1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
142	RRTETTVKKVVKTVT
146	TTVKKVVKTVTTRTV
622	AASCFGAKKGKDEWF
623	ASCFGAKKGKDEWFS
633	DEWFSRGKKPIEDPA
84	RQKFSDLKLNGPQDH

Function

Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476)

Protein Sequence

10 MDDSEVESTA 20 SILASVKEQE 30 AQFEKLTRAL 40 EEERRHVSAQ 50 LERVRVSPQD 60 ANPLMANGTL 70 TRRHQNGRFV 80 GDADLERQKF 90 SDLKLNGPQD 100 HSHLLYSTIP 110 RMQEPGQIVE 120 TYTEEDPEGA 130 MSVVSVETSD 140 DGTTRRTETT 150 VKKVVKTVTT 160 RTVQPVAMGP 170 DGLPVDASSV 180 SNNYIQTLGR 190 DFRKNGNGGP 200 GPYVGQAGTA 210 TLPRNFHYPP 220 DGYSRHYEDG 230 YPGGSDNYGS 240 LSRVTRIEER 250 YRPSMEGYRA 260 PSRQDVYGPQ 270 PQVRVGGSSV 280 DLHRFHPEPY 290 GLEDDQRSMG 300 YDDLDYGMMS 310 DYGTARRTGT 320 PSDPRRRLRS 330 YEDMIGEEVP 340 SDQYYWAPLA 350 QHERGSLASL 360 DSLRKGGPPP 370 PNWRQPELPE 380 VIAMLGFRLD 390 AVKSNAAAYL 400 QHLCYRNDKV 410 KTDVRKLKGI 420 PVLVGLLDHP 430 KKEVHLGACG 440 ALKNISFGRD 450 QDNKIAIKNC 460 DGVPALVRLL 470 RKARDMDLTE 480 VITGTLWNLS 490 SHDSIKMEIV 500 DHALHALTDE 510 VIIPHSGWER 520 EPNEDCKPRH 530 IEWESVLTNT 540 AGCLRNVSSE 550 RSEARRKLRE 560 CDGLVDALIF 570 IVQAEIGQKD 580 SDSKLVENCV 590 CLLRNLSYQV 600 HREIPQAERY 610 QEAAPNVANN 620 TGPHAASCFG 630 AKKGKDEWFS 640 RGKKPIEDPA 650 NDTVDFPKRT 660 SPARGYELLF 670 QPEVVRIYIS 680 LLKESKTPAI 690 LEASAGAIQN 700 LCAGRWTYGR 710 YIRSALRQEK 720 ALSAIADLLT 730 NEHERVVKAA 740 SGALRNLAVD 750 ARNKELIGKH 760 AIPNLVKNLP 770 GGQQNSSWNF 780 SEDTVISILN 790 TINEVIAENL 800 EAAKKLRETQ 810 GIEKLVLINK 820 SGNRSEKEVR 830 AAALVLQTIW 840 GYKELRKPLE 850 KEGWKKSDFQ 860 VNLNNASRSQ 870 SSHSYDDSTL 880 PLIDRNQKSD 890 KKPDREEIQM 900 SNMGSNTKSL 910 DNNYSTPNER 920 GDHNRTLDRS 930 GDLGDMEPLK 940 GTTPLMQDEG 950 QESLEEELDV 960 LVLDDEGGQV SYPSMQKI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0016342	catenin complex
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0098632	cell-cell adhesion mediator activity
Molecular Function	GO:0019902	phosphatase binding
Molecular Function	GO:0019212	phosphatase inhibitor activity
Molecular Function	GO:0140311	protein sequestering activity
Molecular Function	GO:0005102	signaling receptor binding
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0044331	cell-cell adhesion mediated by cadherin
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:1905554	negative regulation of blood vessel branching
Biological Process	GO:0010829	negative regulation of D-glucose transmembrane transport
Biological Process	GO:1902532	negative regulation of intracellular signal transduction
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0150107	positive regulation of protein localization to cell-cell junction
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process	GO:0016055	Wnt signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.