Search Results

Overview

Uniprot IDO60749
Protein NameSorting nexin-2
Gene NameSNX2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
116 IAPRIESKSMSAPVI
223 MTKVKVGKEDSSSTE
287 GILRMVNKAADAVNK
294 KAADAVNKMTIKMNE
335 EALVCHRKELSANTA
404 IRLIAAVKGVFDHRM

Function

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901)

Protein Sequence

10 MAAEREPPPL 20 GDGKPTDFED 30 LEDGEDLFTS 40 TVSTLESSPS 50 SPEPASLPAE 60 DISANSNGPK 70 PTEVVLDDDR 80 EDLFAEATEE 90 VSLDSPEREP 100 ILSSEPSPAV 110 TPVTPTTLIA 120 PRIESKSMSA 130 PVIFDRSREE 140 IEEEANGDIF 150 DIEIGVSDPE 160 KVGDGMNAYM 170 AYRVTTKTSL 180 SMFSKSEFSV 190 KRRFSDFLGL 200 HSKLASKYLH 210 VGYIVPPAPE 220 KSIVGMTKVK 230 VGKEDSSSTE 240 FVEKRRAALE 250 RYLQRTVKHP 260 TLLQDPDLRQ 270 FLESSELPRA 280 VNTQALSGAG 290 ILRMVNKAAD 300 AVNKMTIKMN 310 ESDAWFEEKQ 320 QQFENLDQQL 330 RKLHVSVEAL 340 VCHRKELSAN 350 TAAFAKSAAM 360 LGNSEDHTAL 370 SRALSQLAEV 380 EEKIDQLHQE 390 QAFADFYMFS 400 ELLSDYIRLI 410 AAVKGVFDHR 420 MKCWQKWEDA 430 QITLLKKREA 440 EAKMMVANKP 450 DKIQQAKNEI 460 REWEAKVQQG 470 ERDFEQISKT 480 IRKEVGRFEK 490 ERVKDFKTVI 500 IKYLESLVQT 510 QQQLIKYWEA FLPEAKAIA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016020 membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0030904 retromer complex
Cellular Component GO:0030905 retromer, tubulation complex
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005154 epidermal growth factor receptor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:1990460 leptin receptor binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:1990459 transferrin receptor binding
Biological Process GO:0034498 early endosome to Golgi transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0072673 lamellipodium morphogenesis
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.