Search Results

Overview

Uniprot IDO60763
Protein NameGeneral vesicular transport factor p115
Gene NameUSO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
626 ELEGVITKAIYKSSE
924 DQKILSLKNKLKDLG

Function

General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity

Protein Sequence

10 MNFLRGVMGG 20 QSAGPQHTEA 30 ETIQKLCDRV 40 ASSTLLDDRR 50 NAVRALKSLS 60 KKYRLEVGIQ 70 AMEHLIHVLQ 80 TDRSDSEIIG 90 YALDTLYNII 100 SNEEEEEVEE 110 NSTRQSEDLG 120 SQFTEIFIKQ 130 QENVTLLLSL 140 LEEFDFHVRW 150 PGVKLLTSLL 160 KQLGPQVQQI 170 ILVSPMGVSR 180 LMDLLADSRE 190 VIRNDGVLLL 200 QALTRSNGAI 210 QKIVAFENAF 220 ERLLDIISEE 230 GNSDGGIVVE 240 DCLILLQNLL 250 KNNNSNQNFF 260 KEGSYIQRMK 270 PWFEVGDENS 280 GWSAQKVTNL 290 HLMLQLVRVL 300 VSPTNPPGAT 310 SSCQKAMFQC 320 GLLQQLCTIL 330 MATGVPADIL 340 TETINTVSEV 350 IRGCQVNQDY 360 FASVNAPSNP 370 PRPAIVVLLM 380 SMVNERQPFV 390 LRCAVLYCFQ 400 CFLYKNQKGQ 410 GEIVSTLLPS 420 TIDATGNSVS 430 AGQLLCGGLF 440 STDSLSNWCA 450 AVALAHALQE 460 NATQKEQLLR 470 VQLATSIGNP 480 PVSLLQQCTN 490 ILSQGSKIQT 500 RVGLLMLLCT 510 WLSNCPIAVT 520 HFLHNSANVP 530 FLTGQIAENL 540 GEEEQLVQGL 550 CALLLGISIY 560 FNDNSLESYM 570 KEKLKQLIEK 580 RIGKENFIEK 590 LGFISKHELY 600 SRASQKPQPN 610 FPSPEYMIFD 620 HEFTKLVKEL 630 EGVITKAIYK 640 SSEEDKKEEE 650 VKKTLEQHDN 660 IVTHYKNMIR 670 EQDLQLEELR 680 QQVSTLKCQN 690 EQLQTAVTQQ 700 VSQIQQHKDQ 710 YNLLKIQLGK 720 DNQHQGSYSE 730 GAQMNGIQPE 740 EIGRLREEIE 750 ELKRNQELLQ 760 SQLTEKDSMI 770 ENMKSSQTSG 780 TNEQSSAIVS 790 ARDSEQVAEL 800 KQELATLKSQ 810 LNSQSVEITK 820 LQTEKQELLQ 830 KTEAFAKSVE 840 VQGETETIIA 850 TKTTDVEGRL 860 SALLQETKEL 870 KNEIKALSEE 880 RTAIKEQLDS 890 SNSTIAILQT 900 EKDKLELEIT 910 DSKKEQDDLL 920 VLLADQDQKI 930 LSLKNKLKDL 940 GHPVEEEDEL 950 ESGDQEDEDD 960 ESEDPGKDLD HI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0012507 ER to Golgi transport vesicle membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005795 Golgi stack
Cellular Component GO:0016020 membrane
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0030133 transport vesicle
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0048211 Golgi vesicle docking
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0061025 membrane fusion
Biological Process GO:0045056 transcytosis
Biological Process GO:0048280 vesicle fusion with Golgi apparatus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.