Search Results
Overview
| Uniprot ID | O60814 |
|---|---|
| Protein Name | Histone H2B type 1-K |
| Gene Name | H2BC12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | LLPGELAKHAVSEGT |
| 117 | HAVSEGTKAVTKYTS |
| 12 | AKSAPAPKKGSKKAV |
| 121 | EGTKAVTKYTSAK** |
| 16 | PAPKKGSKKAVTKAQ |
| 17 | APKKGSKKAVTKAQK |
| 21 | GSKKAVTKAQKKDGK |
| 35 | KKRKRSRKESYSVYV |
| 47 | VYVYKVLKQVHPDTG |
| 6 | **MPEPAKSAPAPKK |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0050829 | defense response to Gram-negative bacterium |
| Biological Process | GO:0050830 | defense response to Gram-positive bacterium |
| Biological Process | GO:0002227 | innate immune response in mucosa |
| Biological Process | GO:0031640 | killing of cells of another organism |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.