Search Results
Overview
| Uniprot ID | O60829 |
|---|---|
| Protein Name | P antigen family member 4 |
| Gene Name | PAGE4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 90 | EKTPPNPKHAKTKEA |
Function
Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679)
Protein Sequence
10
MSARVRSRSR
20
GRGDGQEAPD
30
VVAFVAPGES
40
QQEEPPTDNQ
50
DIEPGQEREG
60
TPPIEERKVE
70
GDCQEMDLEK
80
TRSERGDGSD
90
VKEKTPPNPK
100
HAKTKEAGDG
QP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| Biological Process | GO:0032872 | regulation of stress-activated MAPK cascade |
| Biological Process | GO:0042594 | response to starvation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.