Search Results

Overview

Uniprot IDO60870
Protein NameDNA/RNA-binding protein KIN17
Gene NameKIN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
209 KVTFNLSKGACSSSG
221 SSGATSSKSSTLGPS
231 TLGPSALKTIGSSAS

Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro

Protein Sequence

10 MGKSDFLTPK 20 AIANRIKSKG 30 LQKLRWYCQM 40 CQKQCRDENG 50 FKCHCMSESH 60 QRQLLLASEN 70 PQQFMDYFSE 80 EFRNDFLELL 90 RRRFGTKRVH 100 NNIVYNEYIS 110 HREHIHMNAT 120 QWETLTDFTK 130 WLGREGLCKV 140 DETPKGWYIQ 150 YIDRDPETIR 160 RQLELEKKKK 170 QDLDDEEKTA 180 KFIEEQVRRG 190 LEGKEQEVPT 200 FTELSRENDE 210 EKVTFNLSKG 220 ACSSSGATSS 230 KSSTLGPSAL 240 KTIGSSASVK 250 RKESSQSSTQ 260 SKEKKKKKSA 270 LDEIMEIEEE 280 KKRTARTDYW 290 LQPEIIVKII 300 TKKLGEKYHK 310 KKAIVKEVID 320 KYTAVVKMID 330 SGDKLKLDQT 340 HLETVIPAPG 350 KRILVLNGGY 360 RGNEGTLESI 370 NEKTFSATIV 380 IETGPLKGRR 390 VEGIQYEDIS KLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006310 DNA recombination
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.