Search Results

Overview

Uniprot ID	O60879
Protein Name	Protein diaphanous homolog 2
Gene Name	DIAPH2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
156	SGGLKNSKHECTLSS
686	ATQIKVQKNAEALEE

Function

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton

Protein Sequence

10 MEQPGAAASG 20 AGGGSEEPGG 30 GRSNKRSAGN 40 RAANEEETKN 50 KPKLNIQIKT 60 LADDVRDRIT 70 SFRKSTVKKE 80 KPLIQHPIDS 90 QVAMSEFPAA 100 QPLYDERSLN 110 LSEKEVLDLF 120 EKMMEDMNLN 130 EEKKAPLRNK 140 DFTTKREMVV 150 QYISATAKSG 160 GLKNSKHECT 170 LSSQEYVHEL 180 RSGISDEKLL 190 NCLESLRVSL 200 TSNPVSWVNN 210 FGHEGLGLLL 220 DELEKLLDKK 230 QQENIDKKNQ 240 YKLIQCLKAF 250 MNNKFGLQRI 260 LGDERSLLLL 270 ARAIDPKQPN 280 MMTEIVKILS 290 AICIVGEENI 300 LDKLLGAITT 310 AAERNNRERF 320 SPIVEGLENQ 330 EALQLQVACM 340 QFINALVTSP 350 YELDFRIHLR 360 NEFLRSGLKT 370 MLPDLKEKEN 380 DELDIQLKVF 390 DENKEDDLTE 400 LSHRLNDIRA 410 EMDDMNEVYH 420 LLYNMLKDTA 430 AENYFLSILQ 440 HFLLIRNDYY 450 IRPQYYKIIE 460 ECVSQIVLHC 470 SGMDPDFKYR 480 QRLDIDLTHL 490 IDSCVNKAKV 500 EESEQKAAEF 510 SKKFDEEFTA 520 RQEAQAELQK 530 RDEKIKELEA 540 EIQQLRTQAQ 550 VLSSSSGIPG 560 PPAAPPLPGV 570 GPPPPPPAPP 580 LPGGAPLPPP 590 PPPLPGMMGI 600 PPPPPPPLLF 610 GGPPPPPPLG 620 GVPPPPGISL 630 NLPYGMKQKK 640 MYKPEVSMKR 650 INWSKIEPTE 660 LSENCFWLRV 670 KEDKFENPDL 680 FAKLALNFAT 690 QIKVQKNAEA 700 LEEKKTGPTK 710 KKVKELRILD 720 PKTAQNLSIF 730 LGSYRMPYED 740 IRNVILEVNE 750 DMLSEALIQN 760 LVKHLPEQKI 770 LNELAELKNE 780 YDDLCEPEQF 790 GVVMSSVKML 800 QPRLSSILFK 810 LTFEEHINNI 820 KPSIIAVTLA 830 CEELKKSESF 840 NRLLELVLLV 850 GNYMNSGSRN 860 AQSLGFKINF 870 LCKIRDTKSA 880 DQKTTLLHFI 890 ADICEEKYRD 900 ILKFPEELEH 910 VESASKVSAQ 920 ILKSNLASME 930 QQIVHLERDI 940 KKFPQAENQH 950 DKFVEKMTSF 960 TKTAREQYEK 970 LSTMHNNMMK 980 LYENLGEYFI 990 FDSKTVSIEE 1000 FFGDLNNFRT 1010 LFLEAVRENN 1020 KRREMEEKTR 1030 RAKLAKEKAE 1040 QEKLERQKKK 1050 KQLIDINKEG 1060 DETGVMDNLL 1070 EALQSGAAFR 1080 DRRKRIPRNP 1090 DNRRVPLERS 1100 RSRHNGAISS K

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005884	actin filament
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0030041	actin filament polymerization
Biological Process	GO:0007292	female gamete generation
Biological Process	GO:0048477	oogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.