Search Results

Overview

Uniprot IDO60884
Protein NameDnaJ homolog subfamily A member 2
Gene NameDNAJA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
134 LYNGKTTKLQLSKNV
152 ACSGQGGKSGAVQKC
39 AKEYHPDKNPNAGDK

Function

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877)

Protein Sequence

10 MANVADTKLY 20 DILGVPPGAS 30 ENELKKAYRK 40 LAKEYHPDKN 50 PNAGDKFKEI 60 SFAYEVLSNP 70 EKRELYDRYG 80 EQGLREGSGG 90 GGGMDDIFSH 100 IFGGGLFGFM 110 GNQSRSRNGR 120 RRGEDMMHPL 130 KVSLEDLYNG 140 KTTKLQLSKN 150 VLCSACSGQG 160 GKSGAVQKCS 170 ACRGRGVRIM 180 IRQLAPGMVQ 190 QMQSVCSDCN 200 GEGEVINEKD 210 RCKKCEGKKV 220 IKEVKILEVH 230 VDKGMKHGQR 240 ITFTGEADQA 250 PGVEPGDIVL 260 LLQEKEHEVF 270 QRDGNDLHMT 280 YKIGLVEALC 290 GFQFTFKHLD 300 GRQIVVKYPP 310 GKVIEPGCVR 320 VVRGEGMPQY 330 RNPFEKGDLY 340 IKFDVQFPEN 350 NWINPDKLSE 360 LEDLLPSRPE 370 VPNIIGETEE 380 VELQEFDSTR 390 GSGGGQRREA 400 YNDSSDEESS 410 SHHGPGVQCA HQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0001671 ATPase activator activity
Molecular Function GO:0030544 Hsp70 protein binding
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0051082 unfolded protein binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0042026 protein refolding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.