Search Results
Overview
| Uniprot ID | O60907 |
|---|---|
| Protein Name | F-box-like/WD repeat-containing protein TBL1X |
| Gene Name | TBL1X |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | VSHQNPSKNREATVN |
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272)
Protein Sequence
10
MTELAGASSS
20
CCHRPAGRGA
30
MQSVLHHFQR
40
LRGREGGSHF
50
INTSSPRGEA
60
KMSITSDEVN
70
FLVYRYLQES
80
GFSHSAFTFG
90
IESHISQSNI
100
NGTLVPPAAL
110
ISILQKGLQY
120
VEAEISINED
130
GTVFDGRPIE
140
SLSLIDAVMP
150
DVVQTRQQAF
160
REKLAQQQAS
170
AAAAAAAATA
180
AATAATTTSA
190
GVSHQNPSKN
200
REATVNGEEN
210
RAHSVNNHAK
220
PMEIDGEVEI
230
PSSKATVLRG
240
HESEVFICAW
250
NPVSDLLASG
260
SGDSTARIWN
270
LNENSNGGST
280
QLVLRHCIRE
290
GGHDVPSNKD
300
VTSLDWNTNG
310
TLLATGSYDG
320
FARIWTEDGN
330
LASTLGQHKG
340
PIFALKWNRK
350
GNYILSAGVD
360
KTTIIWDAHT
370
GEAKQQFPFH
380
SAPALDVDWQ
390
NNTTFASCST
400
DMCIHVCRLG
410
CDRPVKTFQG
420
HTNEVNAIKW
430
DPSGMLLASC
440
SDDMTLKIWS
450
MKQEVCIHDL
460
QAHNKEIYTI
470
KWSPTGPATS
480
NPNSNIMLAS
490
ASFDSTVRLW
500
DIERGVCTHT
510
LTKHQEPVYS
520
VAFSPDGKYL
530
ASGSFDKCVH
540
IWNTQSGNLV
550
HSYRGTGGIF
560
EVCWNARGDK
570
VGASASDGSV
CVLDLRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.