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Overview

Uniprot IDO60927
Protein NameE3 ubiquitin-protein ligase PPP1R11
Gene NamePPP1R11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
31 ENRSLTIKLRKRKPE
40 RKRKPEKKVEWTSDT
59 HMGRRSSKCCCIYEK

Function

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442)

Protein Sequence

10 MAEAGAGLSE 20 TVTETTVTVT 30 TEPENRSLTI 40 KLRKRKPEKK 50 VEWTSDTVDN 60 EHMGRRSSKC 70 CCIYEKPRAF 80 GESSTESDEE 90 EEEGCGHTHC 100 VRGHRKGRRR 110 ATLGPTPTTP 120 PQPPDPSQPP PGPMQH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0008157 protein phosphatase 1 binding
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Molecular Function GO:0004865 protein serine/threonine phosphatase inhibitor activity
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0001818 negative regulation of cytokine production
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.