Search Results
Overview
| Uniprot ID | O60942 |
|---|---|
| Protein Name | mRNA-capping enzyme |
| Gene Name | RNGTT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | GSSASFGKRRKERLK |
| 591 | LMPPPPPKRPRPLT* |
Function
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate
Protein Sequence
10
MAHNKIPPRW
20
LNCPRRGQPV
30
AGRFLPLKTM
40
LGPRYDSQVA
50
EENRFHPSML
60
SNYLKSLKVK
70
MGLLVDLTNT
80
SRFYDRNDIE
90
KEGIKYIKLQ
100
CKGHGECPTT
110
ENTETFIRLC
120
ERFNERNPPE
130
LIGVHCTHGF
140
NRTGFLICAF
150
LVEKMDWSIE
160
AAVATFAQAR
170
PPGIYKGDYL
180
KELFRRYGDI
190
EEAPPPPLLP
200
DWCFEDDEDE
210
DEDEDGKKES
220
EPGSSASFGK
230
RRKERLKLGA
240
IFLEGVTVKG
250
VTQVTTQPKL
260
GEVQQKCHQF
270
CGWEGSGFPG
280
AQPVSMDKQN
290
IKLLDLKPYK
300
VSWKADGTRY
310
MMLIDGTNEV
320
FMIDRDNSVF
330
HVSNLEFPFR
340
KDLRMHLSNT
350
LLDGEMIIDR
360
VNGQAVPRYL
370
IYDIIKFNSQ
380
PVGDCDFNVR
390
LQCIEREIIS
400
PRHEKMKTGL
410
IDKTQEPFSV
420
RNKPFFDICT
430
SRKLLEGNFA
440
KEVSHEMDGL
450
IFQPTGKYKP
460
GRCDDILKWK
470
PPSLNSVDFR
480
LKITRMGGEG
490
LLPQNVGLLY
500
VGGYERPFAQ
510
IKVTKELKQY
520
DNKIIECKFE
530
NNSWVFMRQR
540
TDKSFPNAYN
550
TAMAVCNSIS
560
NPVTKEMLFE
570
FIDRCTAASQ
580
GQKRKHHLDP
590
DTELMPPPPP
KRPRPLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0050355 | inorganic triphosphate phosphatase activity |
| Molecular Function | GO:0140818 | mRNA 5'-triphosphate monophosphatase activity |
| Molecular Function | GO:0004484 | mRNA guanylyltransferase activity |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0004651 | polynucleotide 5'-phosphatase activity |
| Molecular Function | GO:0008192 | RNA guanylyltransferase activity |
| Biological Process | GO:0006370 | 7-methylguanosine mRNA capping |
| Biological Process | GO:0006396 | RNA processing |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.