Search Results
Overview
| Uniprot ID | O70188 |
|---|---|
| Protein Name | Nuclear factor 1 |
| Gene Name | Nfic |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 280 | STSSSGSKRHKSGSM |
Function
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Protein Sequence
10
MYSSPLCLTQ
20
DEFHPFIEAL
30
LPHVRAFAYT
40
WFNLQARKRK
50
YFKKHEKRMS
60
KDEERAVKDE
70
LLGEKAEVKQ
80
KWASRLLAKL
90
RKDIRPECRE
100
DFVLAVTGKK
110
APGCVLSNPD
120
QKGKMRRIDC
130
LRQADKVWRL
140
DLVMVILFKG
150
IPLESTDGER
160
LVKAAACAHP
170
VLCVQPHHIG
180
VAVKELDLYL
190
AYFVRERDAE
200
QSSSPRTGVG
210
SDQEDSKPIT
220
LDTTDFQESF
230
VTSGVFSVTE
240
LIQVSRTPVV
250
TGTGPNFSLG
260
ELQGHLAYDL
270
NPASAGMRRT
280
LPSTSSSGSK
290
RHKSGSMEED
300
VDTSPGGDYY
310
TSPNSPTSSS
320
RNWTEDMEGG
330
ISSPVKKTEM
340
DKSPFNSPSP
350
QDSPRLSSFT
360
QHHRPVIAVH
370
SGIARSPHPS
380
SALHFPATPI
390
LPQTASTYFP
400
HTAIRYPPHL
410
NPQDPLKDLV
420
SLACDPATQQ
430
PGPPALRPAR
PLQTVPLWD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.