Search Results
Overview
| Uniprot ID | O70250 |
|---|---|
| Protein Name | Phosphoglycerate mutase 2 |
| Gene Name | Pgam2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | GGLTGLNKAETAAKH |
| 106 | NKAETAAKHGEEQVK |
| 113 | KHGEEQVKIWRRSFD |
| 129 | PPPPMDEKHNYYTSI |
| 138 | NYYTSISKDRRYAGL |
| 146 | DRRYAGLKPEELPTC |
| 157 | LPTCESLKDTIARAL |
| 241 | GDEETVRKAMEAVAA |
| 251 | EAVAAQGKAK***** |
Function
Catalyzes the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity
Protein Sequence
10
MTTHRLVMVR
20
HGESLWNQEN
30
RFCGWFDAEL
40
SEKGAEEAKR
50
GATAIKDAKI
60
EFDICYTSVL
70
KRAIRTLWTI
80
LDVTDQMWVP
90
VVRTWRLNER
100
HYGGLTGLNK
110
AETAAKHGEE
120
QVKIWRRSFD
130
TPPPPMDEKH
140
NYYTSISKDR
150
RYAGLKPEEL
160
PTCESLKDTI
170
ARALPFWNEE
180
IAPKIKAGQR
190
VLIAAHGNSL
200
RGIVKHLEGM
210
SDQAIMELNL
220
PTGIPIVYEL
230
DQNLKPTKPM
240
RFLGDEETVR
250
KAMEAVAAQG
KAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990917 | ooplasm |
| Molecular Function | GO:0004082 | bisphosphoglycerate mutase activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004619 | phosphoglycerate mutase activity |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0046689 | response to mercury ion |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0006941 | striated muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.