Search Results
Overview
| Uniprot ID | O70433 |
|---|---|
| Protein Name | Four and a half LIM domains protein 2 |
| Gene Name | Fhl2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | LQCVQCKKPITTGGV |
| 252 | HNDCFNCKKCSLSLV |
| 253 | NDCFNCKKCSLSLVG |
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)
Protein Sequence
10
MTERFDCHHC
20
NESLYGKKYI
30
LKEENPHCVA
40
CFEELYANTC
50
EECGTPIGCD
60
CKDLSYKDRH
70
WHEGCFHCSR
80
CGSSLVDKPF
90
AAKEEQLLCT
100
DCYSNEYSSK
110
CQECKKTIMP
120
GTRKMEYKGS
130
SWHETCFTCQ
140
RCQQPIGTKS
150
FIPKENQNFC
160
VPCYEKQYAL
170
QCVQCKKPIT
180
TGGVTYREQP
190
WHKECFVCTA
200
CKKQLSGQRF
210
TARDEFPYCL
220
TCFCDLYAKK
230
CAGCTNPISG
240
LGGTKYISFE
250
ERQWHNDCFN
260
CKKCSLSLVG
270
RGFLTERDDI
LCPDCGKDI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0043425 | bHLH transcription factor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008134 | transcription factor binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0055014 | atrial cardiac muscle cell development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0055015 | ventricular cardiac muscle cell development |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.