Search Results

Overview

Uniprot IDO70468
Protein NameMyosin-binding protein C, cardiac-type
Gene NameMybpc3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1146 NMVGSSDKAAATKEP
1151 SDKAAATKEPVFIPR
1167 GITYEPPKYKALDFS
1238 VLTLEIRKPCPYDGG
183 VAGASLLKPPVVKWF
193 VVKWFKGKWVDLSSK
200 KWVDLSSKVGQHLQL
364 KSTAFQKKLEPAYQV
414 IFESVGAKRTLTISQ
539 AELIVQEKKLEVYQS
561 AKDQAVFKCEVSDEN
578 GVWLKNGKELVPDNR
587 LVPDNRIKVSHIGRV
6 **MPEPGKKPVSAFN
62 YGLAAEGKRHTLTVR
7 *MPEPGKKPVSAFNK
712 EEWVFDKKLLCETEG
93 SKVKFDLKVTEPAPP

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role

Protein Sequence

10 MPEPGKKPVS 20 AFNKKPRSAE 30 VTAGSAAVFE 40 AETERSGVMV 50 RWQRDGSDIT 60 ANDKYGLAAE 70 GKRHTLTVRD 80 ASPDDQGSYA 90 VIAGSSKVKF 100 DLKVTEPAPP 110 EKAESEVAPG 120 APEEVPAPAT 130 ELEESVSSPE 140 GSVSVTQDGS 150 AAEHQGAPDD 160 PIGLFLMRPQ 170 DGEVTVGGSI 180 VFSARVAGAS 190 LLKPPVVKWF 200 KGKWVDLSSK 210 VGQHLQLHDS 220 YDRASKVYLF 230 ELHITDAQTT 240 SAGGYRCEVS 250 TKDKFDSCNF 260 NLTVHEAIGS 270 GDLDLRSAFR 280 RTSLAGAGRR 290 TSDSHEDAGT 300 PDFSSLLKKR 310 DSFRRDSKLE 320 APAEEDVWEI 330 LRQAPPSEYE 340 RIAFQHGVEA 350 CHRPLKRLKG 360 MKQDEKKSTA 370 FQKKLEPAYQ 380 VNKGHKIRLT 390 VELADPDAEV 400 KWLKNGQEIQ 410 MSGSKYIFES 420 VGAKRTLTIS 430 QCSLADDAAY 440 QCVVGGEKCS 450 TELFVKEPPV 460 LITRSLEDQL 470 VMVGQRVEFE 480 CEVSEEGAQV 490 KWLKDGVELT 500 REETFKYRFK 510 KDGRKHHLII 520 NEATLEDAGH 530 YAVRTSGGQS 540 LAELIVQEKK 550 LEVYQSIADL 560 AVGAKDQAVF 570 KCEVSDENVR 580 GVWLKNGKEL 590 VPDNRIKVSH 600 IGRVHKLTID 610 DVTPADEADY 620 SFVPEGFACN 630 LSAKLHFMEV 640 KIDFVPRQEP 650 PKIHLDCPGS 660 TPDTIVVVTG 670 NKLRLDVPIS 680 GDPAPTVVWQ 690 KTVTQGKKAS 700 AGPHPDAPED 710 AGADEEWVFD 720 KKLLCETEGR 730 VRVETTKDRS 740 VFTVEGAEKE 750 DEGVYTVTVK 760 NPVGEDQVNL 770 TVKVIDVPDA 780 PAAPKISNVG 790 EDSCTVQWEP 800 PAYDGGQPVL 810 GYILERKKKK 820 SYRWMRLNFD 830 LLRELSHEAR 840 RMIEGVAYEM 850 RVYAVNAVGM 860 SRPSPASQPF 870 MPIGPPGEPT 880 HLAVEDVSDT 890 TVSLKWRPPE 900 RVGAGGLDGY 910 SVEYCQEGCS 920 EWTPALQGLT 930 ERRSMLVKDL 940 PTGARLLFRV 950 RAHNVAGPGG 960 PIVTKEPVTV 970 QEILQRPRLQ 980 LPRHLRQTIQ 990 KKVGEPVNLL 1000 IPFQGKPRPQ 1010 VTWTKEGQPL 1020 AGEEVSIRNS 1030 PTDTILFIRA 1040 ARRTHSGTYQ 1050 VTVRIENMED 1060 KATLILQIVD 1070 KPSPPQDIRI 1080 VETWGFNVAL 1090 EWKPPQDDGN 1100 TEIWGYTVQK 1110 ADKKTMEWFT 1120 VLEHYRRTHC 1130 VVSELIIGNG 1140 YYFRVFSHNM 1150 VGSSDKAAAT 1160 KEPVFIPRPG 1170 ITYEPPKYKA 1180 LDFSEAPSFT 1190 QPLANRSIIA 1200 GYNAILCCAV 1210 RGSPKPKISW 1220 FKNGLDLGED 1230 ARFRMFCKQG 1240 VLTLEIRKPC 1250 PYDGGVYVCR 1260 ATNLQGEAQC 1270 ECRLEVRVPQ

Gene Ontology

Classification GO ID Description
Biological Process GO:0045214 sarcomere organization
Cellular Component GO:0031672 A band
Cellular Component GO:0097512 cardiac myofibril
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0031430 M band
Cellular Component GO:0030016 myofibril
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0005863 striated muscle myosin thick filament
Molecular Function GO:0003779 actin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0017022 myosin binding
Molecular Function GO:0032036 myosin heavy chain binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0007155 cell adhesion
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0006936 muscle contraction
Biological Process GO:0031034 myosin filament assembly
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.