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Overview

Uniprot ID	O71037
Protein Name	Endogenous retrovirus group K member 19 Env polyprotein
Gene Name	ERVK-19
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
62	KLTQLATKYLENTKV

Function

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties

Protein Sequence

10 MNPSEMQRKA 20 PPRRRRHRNR 30 APLTHKMNKM 40 VTSEEQMKLP 50 STKKAEPPTW 60 AQLKKLTQLA 70 TKYLENTKVT 80 QTPESMLLAA 90 LMIVSMVVSL 100 PMPAGAAAAN 110 YTYWAYVPFP 120 PLIRAVTWMD 130 NPIEVYVNDS 140 VWVPGPTDDH 150 CPAKPEEEGM 160 MINISIGYRY 170 PPICLGRAPG 180 CLMPAVQNWL 190 VEVPTVSPIS 200 RFTYHMVSGM 210 SLRPRVNYLQ 220 DFSYQRSFKF 230 RPKGKPCPKE 240 IPKESKNTEV 250 LVWEECVANS 260 AVILQNNEFG 270 TIIDWAPRGQ 280 FYHNCSGQTQ 290 SCPSAQVSPA 300 VDSDLTESLD 310 KHKHKKLQSF 320 YPWEWGEKGI 330 STPRPKIISP 340 VSGPEHPELW 350 RLTVASHHIR 360 IWSGNQTLET 370 RDRKPFYTVD 380 LNSSVTVPLQ 390 SCIKPPYMLV 400 VGNIVIKPDS 410 QTITCENCRL 420 LTCIDSTFNW 430 QHRILLVRAR 440 EGVWIPVSMD 450 RPWETSPSIH 460 TLTEVLKGVL 470 NRSKRFIFTL 480 IAVIMGLIAV 490 TATAAVAGVA 500 LHSSVQSVNF 510 VNDWQKNSTR 520 LWNSQSSIDQ 530 KLANQINDLR 540 QTVIWMGDRL 550 MSLEHRFQLQ 560 CDWNTSDFSI 570 TPQIYNESEH 580 HWDMVRRHLQ 590 GREDNLTLDI 600 SKLKEQIFEA 610 SKAHLNLVPG 620 TEAIAGVADG 630 LANLNPVTWV 640 KTIGSTTIIN 650 LILILVCLFC 660 LLLVCRCTQQ 670 LRRDSDHRER 680 AMMTMAVLSK 690 RKGGNVGKSK RDQIVTVSV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005198	structural molecule activity

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.