Overview
| Uniprot ID | O75027 |
|---|
| Protein Name | Iron-sulfur clusters transporter ABCB7, mitochondrial |
|---|
| Gene Name | ABCB7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 251 |
RQTGALSKAIDRGTR |
Function
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)
Protein Sequence
10
MALLAMHSWR
20
WAAAAAAFEK
30
RRHSAILIRP
40
LVSVSGSGPQ
50
WRPHQLGALG
60
TARAYQIPES
70
LKSITWQRLG
80
KGNSGQFLDA
90
AKALQVWPLI
100
EKRTCWHGHA
110
GGGLHTDPKE
120
GLKDVDTRKI
130
IKAMLSYVWP
140
KDRPDLRARV
150
AISLGFLGGA
160
KAMNIVVPFM
170
FKYAVDSLNQ
180
MSGNMLNLSD
190
APNTVATMAT
200
AVLIGYGVSR
210
AGAAFFNEVR
220
NAVFGKVAQN
230
SIRRIAKNVF
240
LHLHNLDLGF
250
HLSRQTGALS
260
KAIDRGTRGI
270
SFVLSALVFN
280
LLPIMFEVML
290
VSGVLYYKCG
300
AQFALVTLGT
310
LGTYTAFTVA
320
VTRWRTRFRI
330
EMNKADNDAG
340
NAAIDSLLNY
350
ETVKYFNNER
360
YEAQRYDGFL
370
KTYETASLKS
380
TSTLAMLNFG
390
QSAIFSVGLT
400
AIMVLASQGI
410
VAGTLTVGDL
420
VMVNGLLFQL
430
SLPLNFLGTV
440
YRETRQALID
450
MNTLFTLLKV
460
DTQIKDKVMA
470
SPLQITPQTA
480
TVAFDNVHFE
490
YIEGQKVLSG
500
ISFEVPAGKK
510
VAIVGGSGSG
520
KSTIVRLLFR
530
FYEPQKGSIY
540
LAGQNIQDVS
550
LESLRRAVGV
560
VPQDAVLFHN
570
TIYYNLLYGN
580
ISASPEEVYA
590
VAKLAGLHDA
600
ILRMPHGYDT
610
QVGERGLKLS
620
GGEKQRVAIA
630
RAILKDPPVI
640
LYDEATSSLD
650
SITEETILGA
660
MKDVVKHRTS
670
IFIAHRLSTV
680
VDADEIIVLD
690
QGKVAERGTH
700
HGLLANPHSI
710
YSEMWHTQSS
720
RVQNHDNPKW
730
EAKKENISKE
740
EERKKLQEEI
750
VNSVKGCGNC
SC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0140481 |
ABC-type iron-sulfur cluster transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042626 |
ATPase-coupled transmembrane transporter activity |
| Molecular Function |
GO:0015232 |
heme transmembrane transporter activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006783 |
heme biosynthetic process |
| Biological Process |
GO:0006879 |
intracellular iron ion homeostasis |
| Biological Process |
GO:0034755 |
iron ion transmembrane transport |
| Biological Process |
GO:0016226 |
iron-sulfur cluster assembly |
| Biological Process |
GO:0140466 |
iron-sulfur cluster export from the mitochondrion |
| Biological Process |
GO:1903427 |
negative regulation of reactive oxygen species biosynthetic process |
| Biological Process |
GO:0070455 |
positive regulation of heme biosynthetic process |
| Biological Process |
GO:1903331 |
positive regulation of iron-sulfur cluster assembly |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.