Overview
| Uniprot ID | O75052 |
|---|
| Protein Name | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
|---|
| Gene Name | NOS1AP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 6 |
**MPSKTKYNLVDDG |
Function
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)
Protein Sequence
10
MPSKTKYNLV
20
DDGHDLRIPL
30
HNEDAFQHGI
40
CFEAKYVGSL
50
DVPRPNSRVE
60
IVAAMRRIRY
70
EFKAKNIKKK
80
KVSIMVSVDG
90
VKVILKKKKK
100
LLLLQKKEWT
110
WDESKMLVMQ
120
DPIYRIFYVS
130
HDSQDLKIFS
140
YIARDGASNI
150
FRCNVFKSKK
160
KSQAMRIVRT
170
VGQAFEVCHK
180
LSLQHTQQNA
190
DGQEDGESER
200
NSNSSGDPGR
210
QLTGAERAST
220
ATAEETDIDA
230
VEVPLPGNDV
240
LEFSRGVTDL
250
DAVGKEGGSH
260
TGSKVSHPQE
270
PMLTASPRML
280
LPSSSSKPPG
290
LGTETPLSTH
300
HQMQLLQQLL
310
QQQQQQTQVA
320
VAQVHLLKDQ
330
LAAEAAARLE
340
AQARVHQLLL
350
QNKDMLQHIS
360
LLVKQVQELE
370
LKLSGQNAMG
380
SQDSLLEITF
390
RSGALPVLCD
400
PTTPKPEDLH
410
SPPLGAGLAD
420
FAHPAGSPLG
430
RRDCLVKLEC
440
FRFLPPEDTP
450
PPAQGEALLG
460
GLELIKFRES
470
GIASEYESNT
480
DESEERDSWS
490
QEELPRLLNV
500
LQRQELGDGL
DDEIAV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0033017 |
sarcoplasmic reticulum membrane |
| Cellular Component |
GO:0030315 |
T-tubule |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0050998 |
nitric-oxide synthase binding |
| Molecular Function |
GO:0030235 |
nitric-oxide synthase regulator activity |
| Molecular Function |
GO:0035591 |
signaling adaptor activity |
| Biological Process |
GO:0006809 |
nitric oxide biosynthetic process |
| Biological Process |
GO:1905026 |
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| Biological Process |
GO:1901381 |
positive regulation of potassium ion transmembrane transport |
| Biological Process |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
| Biological Process |
GO:1902514 |
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process |
GO:0098901 |
regulation of cardiac muscle cell action potential |
| Biological Process |
GO:0003062 |
regulation of heart rate by chemical signal |
| Biological Process |
GO:0045428 |
regulation of nitric oxide biosynthetic process |
| Biological Process |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.