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Overview

Uniprot ID	O75064
Protein Name	DENN domain-containing protein 4B
Gene Name	DENND4B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
610	FFLQGFLKSRERSSH

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

Protein Sequence

10 MAEERPPRLV 20 DYFVVAGLAG 30 NGAPIPEETW 40 VPEPSGPLRP 50 PRPAEPITDV 60 AVIARALGEE 70 VPQGYTCIQA 80 SAGGHPLELS 90 AGLLGGTQPV 100 ICYRRGRDKP 110 PLVELGVLYE 120 GKERPKPGFQ 130 VLDTTPYSHS 140 ANLAPPGPGH 150 PRTYLTYRRA 160 AEGAGLHALG 170 ITDLCLVLPS 180 KGEGTPHTYC 190 RLPRNLNPGM 200 WGPAVYLCYK 210 VGLAKANTLV 220 YEAELLGRYP 230 EEDNEAFPLP 240 ESVPVFCLPM 250 GATIECWPAQ 260 TKYPVPVFST 270 FVLTGAAGDK 280 VYGAALQFYE 290 AFPRARLSER 300 QARALGLLSA 310 VERGRALGGR 320 AVRSRRAIAV 330 LSRWPAFPAF 340 RAFLTFLYRY 350 SVSGPHRLPL 360 EAHISHFIHN 370 VPFPSPQRPR 380 ILVQMSPYDN 390 LLLCQPVSSP 400 LPLSGASFLQ 410 LLQSLGPELA 420 ITLLLAVLTE 430 HKLLVHSLRP 440 DLLTSVCEAL 450 VSMIFPLHWQ 460 CPYIPLCPLV 470 LADVLSAPVP 480 FIVGIHSSYF 490 DLHDPPADVI 500 CVDLDTNTLF 510 QTEEKKLLSP 520 RTLPRRPYKV 530 LLATLTNLYQ 540 QLDQTYTGPE 550 EEASLEFLLT 560 DYEAVCGRRA 570 RLEREVQGAF 580 LRFMACLLKG 590 YRVFLRPLTQ 600 APSEGARDVD 610 NLFFLQGFLK 620 SRERSSHKLY 630 SQLLHTQMFS 640 QFIEECSFGS 650 ARHAALEFFD 660 SCVEKVHPEQ 670 EKPEPTPLVE 680 LEELSGSELT 690 VFITPPEEPA 700 LPEGSESTPQ 710 YCYDGFPELR 720 AELFESLQEQ 730 PGALPVPGPS 740 RSAPSSPAPR 750 RTKQEMKVAQ 760 RMAQKSAAVP 770 ELWARCLLGH 780 CYGLWFLCLP 790 AYVRSAPSRV 800 QALHTAYHVL 810 RQMESGKVVL 820 PDEVCYRVLM 830 QLCSHYGQPV 840 LSVRVMLEMR 850 QAGIVPNTIT 860 YGYYNKAVLE 870 SKWPSGTPGG 880 RLRWAKLRNV 890 VLGAAQFRQP 900 LRERQQQQQQ 910 QQQQQQQQQQ 920 EQVSAHQEAG 930 SSQAEPYLER 940 PSPTRPLQRQ 950 TTWAGRSLRD 960 PASPPGRLVK 970 SGSLGSARGA 980 QPTVEAGVAH 990 MIEALGVLEP 1000 RGSPVPWHDG 1010 SLSDLSLTGE 1020 EPLPGGSPGG 1030 SGSALSAQST 1040 EALEGLSGRG 1050 PKAGGRQDEA 1060 GTPRRGLGAR 1070 LQQLLTPSRH 1080 SPASRIPPPE 1090 LPPDLPPPAR 1100 RSPMDSLLHP 1110 RERPGSTASE 1120 SSASLGSEWD 1130 LSESSLSNLS 1140 LRRSSERLSD 1150 TPGSFQSPSL 1160 EILLSSCSLC 1170 RACDSLVYDE 1180 EIMAGWAPDD 1190 SNLNTTCPFC 1200 ACPFVPLLSV 1210 QTLDSRPSVP 1220 SPKSAGASGS 1230 KDAPVPGGPG 1240 PVLSDRRLCL 1250 ALDEPQLCNG 1260 HMGGASRRVE 1270 SGAWAYLSPL 1280 VLRKELESLV 1290 ENEGSEVLAL 1300 PELPSAHPII 1310 FWNLLWYFQR 1320 LRLPSILPGL 1330 VLASCDGPSH 1340 SQAPSPWLTP 1350 DPASVQVRLL 1360 WDVLTPDPNS 1370 CPPLYVLWRV 1380 HSQIPQRVVW 1390 PGPVPASLSL 1400 ALLESVLRHV 1410 GLNEVHKAVG 1420 LLLETLGPPP 1430 TGLHLQRGIY 1440 REILFLTMAA 1450 LGKDHVDIVA 1460 FDKKYKSAFN 1470 KLASSMGKEE 1480 LRHRRAQMPT 1490 PKAIDCRKCF GAPPEC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005794	Golgi apparatus
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Biological Process	GO:0032483	regulation of Rab protein signal transduction

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.