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Overview

Uniprot ID	O75074
Protein Name	Low-density lipoprotein receptor-related protein 3
Gene Name	LRP3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
3	*****MEKRAAAGLE

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro

Protein Sequence

10 MEKRAAAGLE 20 GAPGARAQLA 30 VVCLVNIFLT 40 GRLSSAVPAL 50 AACSGKLEQH 60 TERRGVIYSP 70 AWPLNYPPGT 80 NCSWYIQGDR 90 GDMITISFRN 100 FDVEESHQCS 110 LDWLLLGPAA 120 PPRQEAFRLC 130 GSAIPPAFIS 140 ARDHVWIFFH 150 SDASSSGQAQ 160 GFRLSYIRGK 170 LGQASCQADE 180 FRCDNGKCLP 190 GPWQCNTVDE 200 CGDGSDEGNC 210 SAPASEPPGS 220 LCPGGTFPCS 230 GARSTRCLPV 240 ERRCDGLQDC 250 GDGSDEAGCP 260 DLACGRRLGS 270 FYGSFASPDL 280 FGAARGPSDL 290 HCTWLVDTQD 300 SRRVLLQLEL 310 RLGYDDYVQV 320 YEGLGERGDR 330 LLQTLSYRSN 340 HRPVSLEAAQ 350 GRLTVAYHAR 360 ARSAGHGFNA 370 TYQVKGYCLP 380 WEQPCGSSSD 390 SDGGSLGDQG 400 CFSEPQRCDG 410 WWHCASGRDE 420 QGCPACPPDQ 430 YPCEGGSGLC 440 YTPADRCNNQ 450 KSCPDGADEK 460 NCFSCQPGTF 470 HCGTNLCIFE 480 TWRCDGQEDC 490 QDGSDEHGCL 500 AAVPRKVITA 510 ALIGSLVCGL 520 LLVIALGCAF 530 KLYSLRTQEY 540 RAFETQMTRL 550 EAEFVRREAP 560 PSYGQLIAQG 570 LIPPVEDFPV 580 YSASQASVLQ 590 NLRTAMRRQM 600 RRHASRRGPS 610 RRRLGRLWNR 620 LFHRPRAPRG 630 QIPLLTAARP 640 SQTVLGDGFL 650 QPAPGAAPDP 660 PAPLMDTGST 670 RAAGDRPPSA 680 PGRAPEVGPS 690 GPPLPSGLRD 700 PECRPVDKDR 710 KVCREPLVDG 720 PAPADAPREP 730 CSAQDPHPQV 740 STASSTLGPH 750 SPEPLGVCRN 760 PPPPCSPMLE 770 ASDDEALLVC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005905	clathrin-coated pit
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Biological Process	GO:0045599	negative regulation of fat cell differentiation
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0045669	positive regulation of osteoblast differentiation
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:0150104	transport across blood-brain barrier

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.