Search Results

Overview

Uniprot IDO75083
Protein NameWD repeat-containing protein 1
Gene NameWDR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 IAWTEDSKRIAVVGE
182 EGPPFKFKFTIGDHS
321 HVIKGHSKSIQCLTV
569 SDPETRVKIQDAHRL
7 *MPYEIKKVFASLPQ
90 RIWDTTQKEHLLKYE

Function

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565)

Protein Sequence

10 MPYEIKKVFA 20 SLPQVERGVS 30 KIIGGDPKGN 40 NFLYTNGKCV 50 ILRNIDNPAL 60 ADIYTEHAHQ 70 VVVAKYAPSG 80 FYIASGDVSG 90 KLRIWDTTQK 100 EHLLKYEYQP 110 FAGKIKDIAW 120 TEDSKRIAVV 130 GEGREKFGAV 140 FLWDSGSSVG 150 EITGHNKVIN 160 SVDIKQSRPY 170 RLATGSDDNC 180 AAFFEGPPFK 190 FKFTIGDHSR 200 FVNCVRFSPD 210 GNRFATASAD 220 GQIYIYDGKT 230 GEKVCALGGS 240 KAHDGGIYAI 250 SWSPDSTHLL 260 SASGDKTSKI 270 WDVSVNSVVS 280 TFPMGSTVLD 290 QQLGCLWQKD 300 HLLSVSLSGY 310 INYLDRNNPS 320 KPLHVIKGHS 330 KSIQCLTVHK 340 NGGKSYIYSG 350 SHDGHINYWD 360 SETGENDSFA 370 GKGHTNQVSR 380 MTVDESGQLI 390 SCSMDDTVRY 400 TSLMLRDYSG 410 QGVVKLDVQP 420 KCVAVGPGGY 430 AVVVCIGQIV 440 LLKDQRKCFS 450 IDNPGYEPEV 460 VAVHPGGDTV 470 AIGGVDGNVR 480 LYSILGTTLK 490 DEGKLLEAKG 500 PVTDVAYSHD 510 GAFLAVCDAS 520 KVVTVFSVAD 530 GYSENNVFYG 540 HHAKIVCLAW 550 SPDNEHFASG 560 GMDMMVYVWT 570 LSDPETRVKI 580 QDAHRLHHVS 590 SLAWLDEHTL 600 VTTSHDASVK EWTITY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0002102 podosome
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0030043 actin filament fragmentation
Biological Process GO:0043297 apical junction assembly
Biological Process GO:0030865 cortical cytoskeleton organization
Biological Process GO:0042247 establishment of planar polarity of follicular epithelium
Biological Process GO:0040011 locomotion
Biological Process GO:0045199 maintenance of epithelial cell apical/basal polarity
Biological Process GO:0002446 neutrophil mediated immunity
Biological Process GO:1990266 neutrophil migration
Biological Process GO:0030220 platelet formation
Biological Process GO:0030834 regulation of actin filament depolymerization
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0007605 sensory perception of sound

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.