Search Results

Overview

Uniprot ID	O75093
Protein Name	Slit homolog 1 protein
Gene Name	SLIT1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
78	NNITRIHKNDFAGLK

Function

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb

Protein Sequence

10 MALTPGWGSS 20 AGPVRPELWL 30 LLWAAAWRLG 40 ASACPALCTC 50 TGTTVDCHGT 60 GLQAIPKNIP 70 RNTERLELNG 80 NNITRIHKND 90 FAGLKQLRVL 100 QLMENQIGAV 110 ERGAFDDMKE 120 LERLRLNRNQ 130 LHMLPELLFQ 140 NNQALSRLDL 150 SENAIQAIPR 160 KAFRGATDLK 170 NLQLDKNQIS 180 CIEEGAFRAL 190 RGLEVLTLNN 200 NNITTIPVSS 210 FNHMPKLRTF 220 RLHSNHLFCD 230 CHLAWLSQWL 240 RQRPTIGLFT 250 QCSGPASLRG 260 LNVAEVQKSE 270 FSCSGQGEAG 280 RVPTCTLSSG 290 SCPAMCTCSN 300 GIVDCRGKGL 310 TAIPANLPET 320 MTEIRLELNG 330 IKSIPPGAFS 340 PYRKLRRIDL 350 SNNQIAEIAP 360 DAFQGLRSLN 370 SLVLYGNKIT 380 DLPRGVFGGL 390 YTLQLLLLNA 400 NKINCIRPDA 410 FQDLQNLSLL 420 SLYDNKIQSL 430 AKGTFTSLRA 440 IQTLHLAQNP 450 FICDCNLKWL 460 ADFLRTNPIE 470 TSGARCASPR 480 RLANKRIGQI 490 KSKKFRCSAK 500 EQYFIPGTED 510 YQLNSECNSD 520 VVCPHKCRCE 530 ANVVECSSLK 540 LTKIPERIPQ 550 STAELRLNNN 560 EISILEATGM 570 FKKLTHLKKI 580 NLSNNKVSEI 590 EDGAFEGAAS 600 VSELHLTANQ 610 LESIRSGMFR 620 GLDGLRTLML 630 RNNRISCIHN 640 DSFTGLRNVR 650 LLSLYDNQIT 660 TVSPGAFDTL 670 QSLSTLNLLA 680 NPFNCNCQLA 690 WLGGWLRKRK 700 IVTGNPRCQN 710 PDFLRQIPLQ 720 DVAFPDFRCE 730 EGQEEGGCLP 740 RPQCPQECAC 750 LDTVVRCSNK 760 HLRALPKGIP 770 KNVTELYLDG 780 NQFTLVPGQL 790 STFKYLQLVD 800 LSNNKISSLS 810 NSSFTNMSQL 820 TTLILSYNAL 830 QCIPPLAFQG 840 LRSLRLLSLH 850 GNDISTLQEG 860 IFADVTSLSH 870 LAIGANPLYC 880 DCHLRWLSSW 890 VKTGYKEPGI 900 ARCAGPQDME 910 GKLLLTTPAK 920 KFECQGPPTL 930 AVQAKCDLCL 940 SSPCQNQGTC 950 HNDPLEVYRC 960 ACPSGYKGRD 970 CEVSLDSCSS 980 GPCENGGTCH 990 AQEGEDAPFT 1000 CSCPTGFEGP 1010 TCGVNTDDCV 1020 DHACANGGVC 1030 VDGVGNYTCQ 1040 CPLQYEGKAC 1050 EQLVDLCSPD 1060 LNPCQHEAQC 1070 VGTPDGPRCE 1080 CMPGYAGDNC 1090 SENQDDCRDH 1100 RCQNGAQCMD 1110 EVNSYSCLCA 1120 EGYSGQLCEI 1130 PPHLPAPKSP 1140 CEGTECQNGA 1150 NCVDQGNRPV 1160 CQCLPGFGGP 1170 ECEKLLSVNF 1180 VDRDTYLQFT 1190 DLQNWPRANI 1200 TLQVSTAEDN 1210 GILLYNGDND 1220 HIAVELYQGH 1230 VRVSYDPGSY 1240 PSSAIYSAET 1250 INDGQFHTVE 1260 LVAFDQMVNL 1270 SIDGGSPMTM 1280 DNFGKHYTLN 1290 SEAPLYVGGM 1300 PVDVNSAAFR 1310 LWQILNGTGF 1320 HGCIRNLYIN 1330 NELQDFTKTQ 1340 MKPGVVPGCE 1350 PCRKLYCLHG 1360 ICQPNATPGP 1370 MCHCEAGWVG 1380 LHCDQPADGP 1390 CHGHKCVHGQ 1400 CVPLDALSYS 1410 CQCQDGYSGA 1420 LCNQAGALAE 1430 PCRGLQCLHG 1440 HCQASGTKGA 1450 HCVCDPGFSG 1460 ELCEQESECR 1470 GDPVRDFHQV 1480 QRGYAICQTT 1490 RPLSWVECRG 1500 SCPGQGCCQG 1510 LRLKRRKFTF 1520 ECSDGTSFAE 1530 EVEKPTKCGC ALCA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0048495	Roundabout binding
Biological Process	GO:0048846	axon extension involved in axon guidance
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0048853	forebrain morphogenesis
Biological Process	GO:0008045	motor neuron axon guidance
Biological Process	GO:0050919	negative chemotaxis
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance
Biological Process	GO:0051964	negative regulation of synapse assembly
Biological Process	GO:0021510	spinal cord development

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.