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Overview

Uniprot ID	O75096
Protein Name	Low-density lipoprotein receptor-related protein 4
Gene Name	LRP4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1280	RSIHRADKGTGSNVI

Function

Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity)

Protein Sequence

10 MRRQWGALLL 20 GALLCAHGLA 30 SSPECACGRS 40 HFTCAVSALG 50 ECTCIPAQWQ 60 CDGDNDCGDH 70 SDEDGCILPT 80 CSPLDFHCDN 90 GKCIRRSWVC 100 DGDNDCEDDS 110 DEQDCPPREC 120 EEDEFPCQNG 130 YCIRSLWHCD 140 GDNDCGDNSD 150 EQCDMRKCSD 160 KEFRCSDGSC 170 IAEHWYCDGD 180 TDCKDGSDEE 190 NCPSAVPAPP 200 CNLEEFQCAY 210 GRCILDIYHC 220 DGDDDCGDWS 230 DESDCSSHQP 240 CRSGEFMCDS 250 GLCINAGWRC 260 DGDADCDDQS 270 DERNCTTSMC 280 TAEQFRCHSG 290 RCVRLSWRCD 300 GEDDCADNSD 310 EENCENTGSP 320 QCALDQFLCW 330 NGRCIGQRKL 340 CNGVNDCGDN 350 SDESPQQNCR 360 PRTGEENCNV 370 NNGGCAQKCQ 380 MVRGAVQCTC 390 HTGYRLTEDG 400 HTCQDVNECA 410 EEGYCSQGCT 420 NSEGAFQCWC 430 ETGYELRPDR 440 RSCKALGPEP 450 VLLFANRIDI 460 RQVLPHRSEY 470 TLLLNNLENA 480 IALDFHHRRE 490 LVFWSDVTLD 500 RILRANLNGS 510 NVEEVVSTGL 520 ESPGGLAVDW 530 VHDKLYWTDS 540 GTSRIEVANL 550 DGAHRKVLLW 560 QNLEKPRAIA 570 LHPMEGTIYW 580 TDWGNTPRIE 590 ASSMDGSGRR 600 IIADTHLFWP 610 NGLTIDYAGR 620 RMYWVDAKHH 630 VIERANLDGS 640 HRKAVISQGL 650 PHPFAITVFE 660 DSLYWTDWHT 670 KSINSANKFT 680 GKNQEIIRNK 690 LHFPMDIHTL 700 HPQRQPAGKN 710 RCGDNNGGCT 720 HLCLPSGQNY 730 TCACPTGFRK 740 ISSHACAQSL 750 DKFLLFARRM 760 DIRRISFDTE 770 DLSDDVIPLA 780 DVRSAVALDW 790 DSRDDHVYWT 800 DVSTDTISRA 810 KWDGTGQEVV 820 VDTSLESPAG 830 LAIDWVTNKL 840 YWTDAGTDRI 850 EVANTDGSMR 860 TVLIWENLDR 870 PRDIVVEPMG 880 GYMYWTDWGA 890 SPKIERAGMD 900 ASGRQVIISS 910 NLTWPNGLAI 920 DYGSQRLYWA 930 DAGMKTIEFA 940 GLDGSKRKVL 950 IGSQLPHPFG 960 LTLYGERIYW 970 TDWQTKSIQS 980 ADRLTGLDRE 990 TLQENLENLM 1000 DIHVFHRRRP 1010 PVSTPCAMEN 1020 GGCSHLCLRS 1030 PNPSGFSCTC 1040 PTGINLLSDG 1050 KTCSPGMNSF 1060 LIFARRIDIR 1070 MVSLDIPYFA 1080 DVVVPINITM 1090 KNTIAIGVDP 1100 QEGKVYWSDS 1110 TLHRISRANL 1120 DGSQHEDIIT 1130 TGLQTTDGLA 1140 VDAIGRKVYW 1150 TDTGTNRIEV 1160 GNLDGSMRKV 1170 LVWQNLDSPR 1180 AIVLYHEMGF 1190 MYWTDWGENA 1200 KLERSGMDGS 1210 DRAVLINNNL 1220 GWPNGLTVDK 1230 ASSQLLWADA 1240 HTERIEAADL 1250 NGANRHTLVS 1260 PVQHPYGLTL 1270 LDSYIYWTDW 1280 QTRSIHRADK 1290 GTGSNVILVR 1300 SNLPGLMDMQ 1310 AVDRAQPLGF 1320 NKCGSRNGGC 1330 SHLCLPRPSG 1340 FSCACPTGIQ 1350 LKGDGKTCDP 1360 SPETYLLFSS 1370 RGSIRRISLD 1380 TSDHTDVHVP 1390 VPELNNVISL 1400 DYDSVDGKVY 1410 YTDVFLDVIR 1420 RADLNGSNME 1430 TVIGRGLKTT 1440 DGLAVDWVAR 1450 NLYWTDTGRN 1460 TIEASRLDGS 1470 CRKVLINNSL 1480 DEPRAIAVFP 1490 RKGYLFWTDW 1500 GHIAKIERAN 1510 LDGSERKVLI 1520 NTDLGWPNGL 1530 TLDYDTRRIY 1540 WVDAHLDRIE 1550 SADLNGKLRQ 1560 VLVSHVSHPF 1570 ALTQQDRWIY 1580 WTDWQTKSIQ 1590 RVDKYSGRNK 1600 ETVLANVEGL 1610 MDIIVVSPQR 1620 QTGTNACGVN 1630 NGGCTHLCFA 1640 RASDFVCACP 1650 DEPDSRPCSL 1660 VPGLVPPAPR 1670 ATGMSEKSPV 1680 LPNTPPTTLY 1690 SSTTRTRTSL 1700 EEVEGRCSER 1710 DARLGLCARS 1720 NDAVPAAPGE 1730 GLHISYAIGG 1740 LLSILLILVV 1750 IAALMLYRHK 1760 KSKFTDPGMG 1770 NLTYSNPSYR 1780 TSTQEVKIEA 1790 IPKPAMYNQL 1800 CYKKEGGPDH 1810 NYTKEKIKIV 1820 EGICLLSGDD 1830 AEWDDLKQLR 1840 SSRGGLLRDH 1850 VCMKTDTVSI 1860 QASSGSLDDT 1870 ETEQLLQEEQ 1880 SECSSVHTAA 1890 TPERRGSLPD 1900 TGWKHERKLS SESQV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0031594	neuromuscular junction
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0044853	plasma membrane raft
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0097060	synaptic membrane
Molecular Function	GO:0034185	apolipoprotein binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0015026	coreceptor activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0030971	receptor tyrosine kinase binding
Molecular Function	GO:0097110	scaffold protein binding
Molecular Function	GO:0001618	virus receptor activity
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process
Biological Process	GO:0048813	dendrite morphogenesis
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway
Biological Process	GO:0048699	generation of neurons
Biological Process	GO:0001822	kidney development
Biological Process	GO:0060173	limb development
Biological Process	GO:0050771	negative regulation of axonogenesis
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway
Biological Process	GO:0030279	negative regulation of ossification
Biological Process	GO:1901631	positive regulation of presynaptic membrane organization
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction
Biological Process	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering
Biological Process	GO:0097104	postsynaptic membrane assembly
Biological Process	GO:0097105	presynaptic membrane assembly
Biological Process	GO:0150052	regulation of postsynapse assembly
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
Biological Process	GO:0050808	synapse organization
Biological Process	GO:0051124	synaptic assembly at neuromuscular junction
Biological Process	GO:0016055	Wnt signaling pathway

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.