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Overview

Uniprot IDO75113
Protein NameNEDD4-binding protein 1
Gene NameN4BP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
412 ETNKTKNKGVYSSTN

Function

Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)

Protein Sequence

10 MAARAVLDEF 20 TAPAEKAELL 30 EQSRGRIEGL 40 FGVSLAVLGA 50 LGAEEPLPAR 60 IWLQLCGAQE 70 AVHSAKEYIK 80 GICEPELEER 90 ECYPKDMHCI 100 FVGAESLFLK 110 SLIQDTCADL 120 CILDIGLLGI 130 RGSAEAVVMA 140 RSHIQQFVKL 150 FENKENLPSS 160 QKESEVKREF 170 KQFVEAHADN 180 YTMDLLILPT 190 SLKKELLTLT 200 QGEENLFETG 210 DDEVIEMRDS 220 QQTEFTQNAA 230 TGLNISRDET 240 VLQEEARNKA 250 GTPVSELTKQ 260 MDTVLSSSPD 270 VLFDPINGLT 280 PDEEALSNER 290 ICQKRRFSDS 300 EERHTKKQFS 310 LENVQEGEIL 320 HDAKTLAGNV 330 IADLSDSSAD 340 SENLSPDIKE 350 TTEEMEYNIL 360 VNFFKTMGYS 370 QEIVEKVIKV 380 YGPSTEPLLL 390 LEEIEKENKR 400 FQEDREFSAG 410 TVYPETNKTK 420 NKGVYSSTNE 430 LTTDSTPKKT 440 QAHTQQNMVE 450 KFSQLPFKVE 460 AKPCTSNCRI 470 NTFRTVPIEQ 480 KHEVWGSNQN 490 YICNTDPETD 500 GLSPSVASPS 510 PKEVNFVSRG 520 ASSHQPRVPL 530 FPENGLHQQP 540 EPLLPNNMKS 550 ACEKRLGCCS 560 SPHSKPNCST 570 LSPPMPLPQL 580 LPSVTDARSA 590 GPSDHIDSSV 600 TGVQRFRDTL 610 KIPYKLELKN 620 EPGRTDLKHI 630 VIDGSNVAIT 640 HGLKKFFSCR 650 GIAIAVEYFW 660 KLGNRNITVF 670 VPQWRTRRDP 680 NVTEQHFLTQ 690 LQELGILSLT 700 PARMVFGERI 710 ASHDDRFLLH 720 LADKTGGIIV 730 TNDNFREFVN 740 ESVSWREIIT 750 KRLLQYTFVG 760 DIFMVPDDPL 770 GRSGPRLEEF 780 LQKEVCLRDM 790 QPLLSALPNV 800 GMFDPSFRVP 810 GTQAASTSHQ 820 PPTRIQGAPS 830 SHWLPQQPHF 840 PLLPALPSLQ 850 QNLPMPAQRS 860 SAETNELREA 870 LLKIFPDSEQ 880 RLKIDQILVA 890 HPYMKDLNAL SAMVLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0004540 RNA nuclease activity
Molecular Function GO:0043130 ubiquitin binding
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0045087 innate immune response
Biological Process GO:0001818 negative regulation of cytokine production
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0045071 negative regulation of viral genome replication
Biological Process GO:0045088 regulation of innate immune response

Reference

PMID: N/A