Search Results

Overview

Uniprot ID	O75122
Protein Name	CLIP-associating protein 2
Gene Name	CLASP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
357	RVSAGSSKASSLPGS
428	EDGRVRAKLSAPLAG
450	SRGRSRTKMVSQSQP
492	VNSASAQKRSKIPRS

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex

Protein Sequence

10 MAMGDDKSFD 20 DEESVDGNRP 30 SSAASAFKVP 40 APKTSGNPAN 50 SARKPGSAGG 60 PKVGGASKEG 70 GAGAVDEDDF 80 IKAFTDVPSI 90 QIYSSRELEE 100 TLNKIREILS 110 DDKHDWDQRA 120 NALKKIRSLL 130 VAGAAQYDCF 140 FQHLRLLDGA 150 LKLSAKDLRS 160 QVVREACITV 170 AHLSTVLGNK 180 FDHGAEAIVP 190 TLFNLVPNSA 200 KVMATSGCAA 210 IRFIIRHTHV 220 PRLIPLITSN 230 CTSKSVPVRR 240 RSFEFLDLLL 250 QEWQTHSLER 260 HAAVLVETIK 270 KGIHDADAEA 280 RVEARKTYMG 290 LRNHFPGEAE 300 TLYNSLEPSY 310 QKSLQTYLKS 320 SGSVASLPQS 330 DRSSSSSQES 340 LNRPFSSKWS 350 TANPSTVAGR 360 VSAGSSKASS 370 LPGSLQRSRS 380 DIDVNAAAGA 390 KAHHAAGQSV 400 RSGRLGAGAL 410 NAGSYASLED 420 TSDKLDGTAS 430 EDGRVRAKLS 440 APLAGMGNAK 450 ADSRGRSRTK 460 MVSQSQPGSR 470 SGSPGRVLTT 480 TALSTVSSGV 490 QRVLVNSASA 500 QKRSKIPRSQ 510 GCSREASPSR 520 LSVARSSRIP 530 RPSVSQGCSR 540 EASRESSRDT 550 SPVRSFQPLA 560 SRHHSRSTGA 570 LYAPEVYGAS 580 GPGYGISQSS 590 RLSSSVSAMR 600 VLNTGSDVEE 610 AVADALKKPA 620 RRRYESYGMH 630 SDDDANSDAS 640 SACSERSYSS 650 RNGSIPTYMR 660 QTEDVAEVLN 670 RCASSNWSER 680 KEGLLGLQNL 690 LKNQRTLSRV 700 ELKRLCEIFT 710 RMFADPHGKR 720 VFSMFLETLV 730 DFIQVHKDDL 740 QDWLFVLLTQ 750 LLKKMGADLL 760 GSVQAKVQKA 770 LDVTRESFPN 780 DLQFNILMRF 790 TVDQTQTPSL 800 KVKVAILKYI 810 ETLAKQMDPG 820 DFINSSETRL 830 AVSRVITWTT 840 EPKSSDVRKA 850 AQSVLISLFE 860 LNTPEFTMLL 870 GALPKTFQDG 880 ATKLLHNHLR 890 NTGNGTQSSM 900 GSPLTRPTPR 910 SPANWSSPLT 920 SPTNTSQNTL 930 SPSAFDYDTE 940 NMNSEDIYSS 950 LRGVTEAIQN 960 FSFRSQEDMN 970 EPLKRDSKKD 980 DGDSMCGGPG 990 MSDPRAGGDA 1000 TDSSQTALDN 1010 KASLLHSMPT 1020 HSSPRSRDYN 1030 PYNYSDSISP 1040 FNKSALKEAM 1050 FDDDADQFPD 1060 DLSLDHSDLV 1070 AELLKELSNH 1080 NERVEERKIA 1090 LYELMKLTQE 1100 ESFSVWDEHF 1110 KTILLLLLET 1120 LGDKEPTIRA 1130 LALKVLREIL 1140 RHQPARFKNY 1150 AELTVMKTLE 1160 AHKDPHKEVV 1170 RSAEEAASVL 1180 ATSISPEQCI 1190 KVLCPIIQTA 1200 DYPINLAAIK 1210 MQTKVIERVS 1220 KETLNLLLPE 1230 IMPGLIQGYD 1240 NSESSVRKAC 1250 VFCLVAVHAV 1260 IGDELKPHLS 1270 QLTGSKMKLL 1280 NLYIKRAQTG 1290 SGGADPTTDV SGQS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0045180	basal cortex
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0030981	cortical microtubule cytoskeleton
Cellular Component	GO:1903754	cortical microtubule plus-end
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005881	cytoplasmic microtubule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005828	kinetochore microtubule
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032587	ruffle membrane
Cellular Component	GO:0005876	spindle microtubule
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0002162	dystroglycan binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0051010	microtubule plus-end binding
Molecular Function	GO:1990782	protein tyrosine kinase binding
Biological Process	GO:0071711	basement membrane organization
Biological Process	GO:0051301	cell division
Biological Process	GO:0040001	establishment of mitotic spindle localization
Biological Process	GO:0007163	establishment or maintenance of cell polarity
Biological Process	GO:0010458	exit from mitosis
Biological Process	GO:0007030	Golgi organization
Biological Process	GO:0034453	microtubule anchoring
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0007020	microtubule nucleation
Biological Process	GO:0031023	microtubule organizing center organization
Biological Process	GO:0090307	mitotic spindle assembly
Biological Process	GO:0007052	mitotic spindle organization
Biological Process	GO:0051895	negative regulation of focal adhesion assembly
Biological Process	GO:0007026	negative regulation of microtubule depolymerization
Biological Process	GO:0051497	negative regulation of stress fiber assembly
Biological Process	GO:1903690	negative regulation of wound healing, spreading of epidermal cells
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
Biological Process	GO:0010634	positive regulation of epithelial cell migration
Biological Process	GO:0045921	positive regulation of exocytosis
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly
Biological Process	GO:0099187	presynaptic cytoskeleton organization
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:0030516	regulation of axon extension
Biological Process	GO:0031113	regulation of microtubule polymerization
Biological Process	GO:0031110	regulation of microtubule polymerization or depolymerization
Biological Process	GO:0032886	regulation of microtubule-based process
Biological Process	GO:0006903	vesicle targeting

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.