Search Results
Overview
| Uniprot ID | O75128 |
|---|---|
| Protein Name | Protein cordon-bleu |
| Gene Name | COBL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 153 | GPPKVPEKSVRLVVN |
Function
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles
Protein Sequence
10
MDAPRASAAK
20
PPTGRKMKAR
30
APPPPGKAAT
40
LHVHSDQKPP
50
HDGALGSQQN
60
LVRMKEALRA
70
STMDVTVVLP
80
SGLEKRSVLN
90
GSHAMMDLLV
100
ELCLQNHLNP
110
SHHALEIRSS
120
ETQQPLSFKP
130
NTLIGTLNVH
140
TVFLKEKVPE
150
EKVKPGPPKV
160
PEKSVRLVVN
170
YLRTQKAVVR
180
VSPEVPLQNI
190
LPVICAKCEV
200
SPEHVVLLRD
210
NIAGEELELS
220
KSLNELGIKE
230
LYAWDNRRET
240
FRKSSLGNDE
250
TDKEKKKFLG
260
FFKVNKRSNS
270
KGCLTTPNSP
280
SMHSRSLTLG
290
PSLSLGSISG
300
VSVKSEMKKR
310
RAPPPPGSGP
320
PVQDKASEKV
330
SLGSQIDLQK
340
KKRRAPAPPP
350
PQPPPPSPLI
360
PNRTEDKEEN
370
RKSTMVSLPL
380
GSGSHCSPDG
390
APQVLSEAEE
400
TVSVGSCFAS
410
EDTTEDSGVM
420
SSPSDIVSLD
430
SQQDSMKYKD
440
KWATDQEDCS
450
DQDLAGTPDL
460
GPQKSPLWEK
470
NGSENSHLRT
480
EKAVTASNDE
490
EDLLIAGEFR
500
KTLAELDEDL
510
EEMEDSYETD
520
TSSLTSSIHG
530
ASNHCPQDAM
540
IPHGDTDAIP
550
VTFIGEVSDD
560
PVDSGLFSNR
570
NNNAGSFDSE
580
GVASRRDSLA
590
PLQAEHSQPH
600
EKAREEVPAL
610
HPASHDVGKG
620
IRVALSNISK
630
DGNLMETAPR
640
VTSFASNLHT
650
DNLNAKVKDK
660
VYGCADGERT
670
QATERVNSQP
680
VNEKDSNDKN
690
AALAPTSWHQ
700
RGQNPGKSYR
710
LKHGLTTYKI
720
IPPKSEMRCY
730
DRDVSLSTGA
740
IKIDELGNLV
750
SPHATGIRII
760
SLSSSVPEAE
770
SQPIGKVREF
780
WRCNSVEKHL
790
GRPSESSARG
800
PPSTPVPTQT
810
QNPESRLQAD
820
PKPISPQQKS
830
AHHEGRNPLG
840
EGRNQPPTMG
850
MGHVRVPAAH
860
TTEVTFLKPQ
870
RRTSSQYVAS
880
AIAKRIGAPK
890
VHADVVRPHG
900
YAEKGYAGKA
910
PVLAAPPVTV
920
KDDRTSSPHS
930
ETQGWKDGAQ
940
WPCVTPPNNH
950
GEDLAVGAPP
960
RGEVIGPHRK
970
LSTQDRPAAI
980
HRSSCFSLVQ
990
SSQRDRVSVG
1000
QSCGFSGKQS
1010
TSSQEASSAS
1020
EPRRAPDGTD
1030
PPPPHTSDTQ
1040
ACSRELVNGS
1050
VRAPGHGEPS
1060
HPPGGSGTES
1070
HILLEREEKP
1080
SVFSTDGNET
1090
DSIWPPSIFG
1100
PKKKFKPVVQ
1110
RPVPKDTSLH
1120
SALMEAIHSA
1130
GGKDRLRKTA
1140
EHTGEGRPAK
1150
LSYTEAEGER
1160
SALLAAIRGH
1170
SGTCSLRKVA
1180
SSASEELQSF
1190
RDAALSAQGS
1200
ESPLLEDLGL
1210
LSPPAIPPPP
1220
PPPSQALSAP
1230
RTASRFSTGT
1240
LSNTADARQA
1250
LMDAIRSGTG
1260
AARLRKVPLL
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0044294 | dendritic growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0003785 | actin monomer binding |
| Biological Process | GO:0051639 | actin filament network formation |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0048669 | collateral sprouting in absence of injury |
| Biological Process | GO:0048565 | digestive tract development |
| Biological Process | GO:0000578 | embryonic axis specification |
| Biological Process | GO:0033504 | floor plate development |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0001843 | neural tube closure |
| Biological Process | GO:0030903 | notochord development |
| Biological Process | GO:1900006 | positive regulation of dendrite development |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0001757 | somite specification |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.