Search Results
Overview
| Uniprot ID | O75131 |
|---|---|
| Protein Name | Copine-3 |
| Gene Name | CPNE3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 253 | EFECINEKKRQKKKS |
| 254 | FECINEKKRQKKKSY |
| 262 | RQKKKSYKNSGVISV |
| 52 | VERTERIKNCLNPQF |
Function
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870)
Protein Sequence
10
MAAQCVTKVA
20
LNVSCANLLD
30
KDIGSKSDPL
40
CVLFLNTSGQ
50
QWYEVERTER
60
IKNCLNPQFS
70
KTFIIDYYFE
80
VVQKLKFGVY
90
DIDNKTIELS
100
DDDFLGECEC
110
TLGQIVSSKK
120
LTRPLVMKTG
130
RPAGKGSITI
140
SAEEIKDNRV
150
VLFEMEARKL
160
DNKDLFGKSD
170
PYLEFHKQTS
180
DGNWLMVHRT
190
EVVKNNLNPV
200
WRPFKISLNS
210
LCYGDMDKTI
220
KVECYDYDND
230
GSHDLIGTFQ
240
TTMTKLKEAS
250
RSSPVEFECI
260
NEKKRQKKKS
270
YKNSGVISVK
280
QCEITVECTF
290
LDYIMGGCQL
300
NFTVGVDFTG
310
SNGDPRSPDS
320
LHYISPNGVN
330
EYLTALWSVG
340
LVIQDYDADK
350
MFPAFGFGAQ
360
IPPQWQVSHE
370
FPMNFNPSNP
380
YCNGIQGIVE
390
AYRSCLPQIK
400
LYGPTNFSPI
410
INHVARFAAA
420
ATQQQTASQY
430
FVLLIITDGV
440
ITDLDETRQA
450
IVNASRLPMS
460
IIIVGVGGAD
470
FSAMEFLDGD
480
GGSLRSPLGE
490
VAIRDIVQFV
500
PFRQFQNAPK
510
EALAQCVLAE
520
IPQQVVGYFN
530
TYKLLPPKNP
ATKQQKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0038128 | ERBB2 signaling pathway |
| Biological Process | GO:0046474 | glycerophospholipid biosynthetic process |
| Biological Process | GO:0030335 | positive regulation of cell migration |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.