Search Results

Overview

Uniprot IDO75152
Protein NameZinc finger CCCH domain-containing protein 11A
Gene NameZC3H11A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 QLSVQQNKLSVQSNP
199 LRVTSVRKPAVNIKQ
221 IKTLEEIKSKKMKEK
288 TERLGKRKFSAGGDS
300 GDSDPPLKRSLAQRL
320 APETNIDKTPKKAQV
329 PKKAQVSKSLKERLG
387 LKTEGPSKTDDSTSG
404 SSSTIRIKTFSEVLA
413 FSEVLAEKKHRQQEA
414 SEVLAEKKHRQQEAE
435 DTTCIKLKIDSEIKK
481 LEEIKLEKALRVQQS
553 TTGVDITKIQVKRCE
643 CAAQTLEKRGKAKPK
654 AKPKVNVKPSVVKVV
665 VKVVSSPKLAPKRKA
698 VLQEPPAKKAAVAVV
699 LQEPPAKKAAVAVVP
764 LSSASTGKPPLSVED

Function

Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722)

Protein Sequence

10 MPNQGEDCYF 20 FFYSTCTKGD 30 SCPFRHCEAA 40 IGNETVCTLW 50 QEGRCFRQVC 60 RFRHMEIDKK 70 RSEIPCYWEN 80 QPTGCQKLNC 90 AFHHNRGRYV 100 DGLFLPPSKT 110 VLPTVPESPE 120 EEVKASQLSV 130 QQNKLSVQSN 140 PSPQLRSVMK 150 VESSENVPSP 160 THPPVVINAA 170 DDDEDDDDQF 180 SEEGDETKTP 190 TLQPTPEVHN 200 GLRVTSVRKP 210 AVNIKQGECL 220 NFGIKTLEEI 230 KSKKMKEKSK 240 KQGEGSSGVS 250 SLLLHPEPVP 260 GPEKENVRTV 270 VRTVTLSTKQ 280 GEEPLVRLSL 290 TERLGKRKFS 300 AGGDSDPPLK 310 RSLAQRLGKK 320 VEAPETNIDK 330 TPKKAQVSKS 340 LKERLGMSAD 350 PDNEDATDKV 360 NKVGEIHVKT 370 LEEILLERAS 380 QKRGELQTKL 390 KTEGPSKTDD 400 STSGARSSST 410 IRIKTFSEVL 420 AEKKHRQQEA 430 ERQKSKKDTT 440 CIKLKIDSEI 450 KKTVVLPPIV 460 ASRGQSEEPA 470 GKTKSMQEVH 480 IKTLEEIKLE 490 KALRVQQSSE 500 SSTSSPSQHE 510 ATPGARRLLR 520 ITKRTGMKEE 530 KNLQEGNEVD 540 SQSSIRTEAK 550 EASGETTGVD 560 ITKIQVKRCE 570 TMREKHMQKQ 580 QEREKSVLTP 590 LRGDVASCNT 600 QVAEKPVLTA 610 VPGITRHLTK 620 RLPTKSSQKV 630 EVETSGIGDS 640 LLNVKCAAQT 650 LEKRGKAKPK 660 VNVKPSVVKV 670 VSSPKLAPKR 680 KAVEMHAAVI 690 AAVKPLSSSS 700 VLQEPPAKKA 710 AVAVVPLVSE 720 DKSVTVPEAE 730 NPRDSLVLPP 740 TQSSSDSSPP 750 EVSGPSSSQM 760 SMKTRRLSSA 770 STGKPPLSVE 780 DDFEKLIWEI 790 SGGKLEAEID 800 LDPGKDEDDL 810 LLELSEMIDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0016973 poly(A)+ mRNA export from nucleus

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.