Overview
| Uniprot ID | O75159 |
|---|
| Protein Name | Suppressor of cytokine signaling 5 |
|---|
| Gene Name | SOCS5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 205 |
SKPLFSNKRKIHLSE |
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling
Protein Sequence
10
MDKVGKMWNN
20
FKYRCQNLFG
30
HEGGSRSENV
40
DMNSNRCLSV
50
KEKNISIGDS
60
TPQQQSSPLR
70
ENIALQLGLS
80
PSKNSSRRNQ
90
NCATEIPQIV
100
EISIEKDNDS
110
CVTPGTRLAR
120
RDSYSRHAPW
130
GGKKKHSCST
140
KTQSSLDADK
150
KFGRTRSGLQ
160
RRERRYGVSS
170
VHDMDSVSSR
180
TVGSRSLRQR
190
LQDTVGLCFP
200
MRTYSKQSKP
210
LFSNKRKIHL
220
SELMLEKCPF
230
PAGSDLAQKW
240
HLIKQHTAPV
250
SPHSTFFDTF
260
DPSLVSTEDE
270
EDRLRERRRL
280
SIEEGVDPPP
290
NAQIHTFEAT
300
AQVNPLYKLG
310
PKLAPGMTEI
320
SGDSSAIPQA
330
NCDSEEDTTT
340
LCLQSRRQKQ
350
RQISGDSHTH
360
VSRQGAWKVH
370
TQIDYIHCLV
380
PDLLQITGNP
390
CYWGVMDRYE
400
AEALLEGKPE
410
GTFLLRDSAQ
420
EDYLFSVSFR
430
RYNRSLHARI
440
EQWNHNFSFD
450
AHDPCVFHSS
460
TVTGLLEHYK
470
DPSSCMFFEP
480
LLTISLNRTF
490
PFSLQYICRA
500
VICRCTTYDG
510
IDGLPLPSML
520
QDFLKEYHYK
530
QKVRVRWLER
EPVKAK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0007175 |
negative regulation of epidermal growth factor-activated receptor activity |
| Biological Process |
GO:0050728 |
negative regulation of inflammatory response |
| Biological Process |
GO:0032715 |
negative regulation of interleukin-6 production |
| Biological Process |
GO:0071638 |
negative regulation of monocyte chemotactic protein-1 production |
| Biological Process |
GO:0009968 |
negative regulation of signal transduction |
| Biological Process |
GO:0045629 |
negative regulation of T-helper 2 cell differentiation |
| Biological Process |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0045627 |
positive regulation of T-helper 1 cell differentiation |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0097699 |
vascular endothelial cell response to fluid shear stress |
| Molecular Function |
GO:0005154 |
epidermal growth factor receptor binding |
| Molecular Function |
GO:0030971 |
receptor tyrosine kinase binding |
| Biological Process |
GO:0007259 |
cell surface receptor signaling pathway via JAK-STAT |
| Biological Process |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
| Biological Process |
GO:0019221 |
cytokine-mediated signaling pathway |
| Biological Process |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.